GRIN2B

Gene Symbol	GRIN2B
Entrez Gene	2904
Alt Symbol	EIEE27, GluN2B, MRD6, NMDAR2B, NR2B, hNR3
Species	Human
Gene Type	protein-coding
Description	glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Other Description	N-methyl D-aspartate receptor subtype 2B|N-methyl-D-aspartate receptor subunit 3|NR3|glutamate [NMDA] receptor subunit epsilon-2|glutamate receptor ionotropic, NMDA 2B|glutamate receptor subunit epsilon-2
Swissprots	Q12919 Q14CU4 Q13225 Q9UM56 Q13224 Q13220
Accessions	EAW96311 Q13224 AB208850 BAD92087 AK091524 BC113618 AAI13619 BC113620 AAI13621 BX648060 U11287 AAB60368 U28758 AAA74930 U28861 AAA69919 U28862 AAA69920 U88963 AAD00659 U90278 AAB49993 XM_005253351 XP_005253408 XM_011520628 XP_011518930 XM_011520629 XP_011518931 XM_011520630 XP_011518932 NM_000834 NP_000825
Function	NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). {ECO:0000250}.
Subcellular Location	Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Tissue Specificity	Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia. {ECO:0000269|PubMed:9547169}.
Top Pathways	Rap1 signaling pathway, Circadian entrainment, Alcoholism, Cocaine addiction, cAMP signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NMDAR2B peptide - ab71176 from Abcam Category Peptide

Human NMDAR2B peptide - ab71177 from Abcam Category Peptide

Human NMDAR2B protein fragment - ab112298 from Abcam Category Protein Source Wheat germ Species Human

Mouse NMDAR2B (phospho S1480) peptide - ab19642 from Abcam Category Peptide

Mouse NMDAR2B (phospho Y1252) peptide - ab19636 from Abcam Category Peptide

Mouse NMDAR2B (unmodified ) peptide - ab19637 from Abcam Category Peptide

Mouse NMDAR2B (unmodified ) peptide - ab19643 from Abcam Category Peptide

NMDAR2B peptide - ab86148 from Abcam Category Peptide

GRIN2B / NMDAR2B / NR2B Antibody Blocking Peptide - LS-E26120 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GRIN2B / NMDAR2B / NR2B Antibody Blocking Peptide - LS-E12473 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NMDAR2B Partial Recombinant Protein - H00002904-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

NMDAR2B blocking peptide - GTX89310-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

NR2B peptide - orb73049 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

GRIN2B Blocking Peptide - 33R-8201 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

NMDAR2B Peptide - AC21-0949-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

NMDAR2B - H00002904-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

NMDAR2B - H00002904-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NMDA Receptor Peptide - 45-970P from ProSci Category Peptide Species Rat

GRIN2B fusion protein - Ag16718 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

GRIN2B fusion protein - ag16318 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human GRIN2B - GRIN2B-29049TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human GRIN2B, His-tagged - GRIN2B-13535H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B) - RPE807Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

NMDAε2 (S1468) Peptide - BS2434P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B) - RPE807Hu01 from Cloud-clone Category Protein Source E.coli Species Human

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