| Gene Symbol |
GRIN2B
|
| Entrez Gene |
2904
|
| Alt Symbol |
EIEE27, GluN2B, MRD6, NMDAR2B, NR2B, hNR3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
|
| Other Description |
N-methyl D-aspartate receptor subtype 2B|N-methyl-D-aspartate receptor subunit 3|NR3|glutamate [NMDA] receptor subunit epsilon-2|glutamate receptor ionotropic, NMDA 2B|glutamate receptor subunit epsilon-2
|
| Swissprots |
Q12919 Q14CU4 Q13225 Q9UM56 Q13224 Q13220
|
| Accessions |
EAW96311 Q13224 AB208850 BAD92087 AK091524 BC113618 AAI13619 BC113620 AAI13621 BX648060 U11287 AAB60368 U28758 AAA74930 U28861 AAA69919 U28862 AAA69920 U88963 AAD00659 U90278 AAB49993 XM_005253351 XP_005253408 XM_011520628 XP_011518930 XM_011520629 XP_011518931 XM_011520630 XP_011518932 NM_000834 NP_000825
|
| Function |
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia. {ECO:0000269|PubMed:9547169}.
|
| Top Pathways |
Rap1 signaling pathway, Circadian entrainment, Alcoholism, Cocaine addiction, cAMP signaling pathway
|
