| Gene Symbol |
XRCC2
|
| Entrez Gene |
7516
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
X-ray repair complementing defective repair in Chinese hamster cells 2
|
| Other Description |
DNA repair protein XRCC2|X-ray repair cross-complementing protein 2
|
| Swissprots |
B2R925 O43543
|
| Accessions |
AAC05802 AAM55241 CAA76597 EAW53967 EAW53968 O43543 AF035587 AAC05369 AK313607 BAG36372 BC042137 AAH42137 CR749256 CAH18112 Y08837 CAA70065 NM_005431 NP_005422
|
| Function |
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2- dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. {ECO:0000269|PubMed:11751635, ECO:0000269|PubMed:11834724, ECO:0000269|PubMed:21276791, ECO:0000269|PubMed:23149936}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:21276791}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21276791}.
|
| Top Pathways |
Homologous recombination
|