XRCC2

Gene Symbol	XRCC2
Entrez Gene	7516
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	X-ray repair complementing defective repair in Chinese hamster cells 2
Other Description	DNA repair protein XRCC2|X-ray repair cross-complementing protein 2
Swissprots	B2R925 O43543
Accessions	AAC05802 AAM55241 CAA76597 EAW53967 EAW53968 O43543 AF035587 AAC05369 AK313607 BAG36372 BC042137 AAH42137 CR749256 CAH18112 Y08837 CAA70065 NM_005431 NP_005422
Function	Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2- dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. {ECO:0000269|PubMed:11751635, ECO:0000269|PubMed:11834724, ECO:0000269|PubMed:21276791, ECO:0000269|PubMed:23149936}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:21276791}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21276791}.
Top Pathways	Homologous recombination

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human XRCC2 full length protein - ab152808 from Abcam Category Protein Source Wheat germ Species Human

Human XRCC2 full length protein - ab177641 from Abcam Category Protein Source E. coli Species Human

XRCC2 Antibody Blocking Peptide - LS-E6589 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

XRCC2 Antibody Blocking Peptide - LS-E21428 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human XRCC2 Protein - H00007516-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

XRCC2-AntibodyN-term-Blocking-peptide - BP19368a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

XRCC2 Blocking Peptide - 33R-1740 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

XRCC2 Blocking Peptide - abx063429 from Abbexa Category Peptide Species Human, Monkey

XRCC2 - H00007516-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

XRCC2 - H00007516-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

XRCC2 fusion protein - ag14421 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

XRCC2 fusion protein - ag14011 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human XRCC2, His-tagged - XRCC2-5013H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human X-ray repair complementing defective repair in Chinese hamster cells 2, His-tagged - XRCC2-412H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant X-Ray Repair Cross Complementing 2 (XRCC2) - RPG147Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

XRCC2 Blocking Peptide - CBP2235 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Monkey

XRCC2 (F240) Peptide - BS1494P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant X-Ray Repair Cross Complementing 2 (XRCC2) - RPG147Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human DNA repair protein XRCC2(XRCC2) - CSB-YP026230HU CSB-EP026230HU CSB-BP026230HU CSB-MP026230HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

XRCC2 - TP308330 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

X-Ray Repair Cross Complementing Protein 2, Recombinant Protein - MBS145798 from MyBioSource Category Protein Prices $140.00, $205.00, $2,665.00 Sizes 5 µg, 20 µg, 1 mg

Human XRCC2 protein - orb260167 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

XRCC2 Peptide, Human - M34GP17594H from Creative Peptides Category Peptide Source Synthetic. Species Human

XRCC2 peptide - orb218098 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg

DNA repair protein XRCC2 (XRCC2), Recombinant Protein - MBS1036399 from MyBioSource Category Protein Prices $1,035.00, $1,035.00, $1,265.00, $1,265.00, $1,600.00, $1,600.00, $2,065.00, $2,065.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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