XRCC2

Gene Symbol XRCC2
Entrez Gene 7516
Alt Symbol -
Species Human
Gene Type protein-coding
Description X-ray repair complementing defective repair in Chinese hamster cells 2
Other Description DNA repair protein XRCC2|X-ray repair cross-complementing protein 2
Swissprots B2R925 O43543
Accessions AAC05802 AAM55241 CAA76597 EAW53967 EAW53968 O43543 AF035587 AAC05369 AK313607 BAG36372 BC042137 AAH42137 CR749256 CAH18112 Y08837 CAA70065 NM_005431 NP_005422
Function Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2- dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. {ECO:0000269|PubMed:11751635, ECO:0000269|PubMed:11834724, ECO:0000269|PubMed:21276791, ECO:0000269|PubMed:23149936}.
Subcellular Location Nucleus {ECO:0000269|PubMed:21276791}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21276791}.
Top Pathways Homologous recombination

XRCC2 CRISPR/Cas9 KO Plasmid (h) - sc-403531 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

XRCC2 HDR Plasmid (h) - sc-403531-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

XRCC2 Double Nickase Plasmid (h) - sc-403531-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

XRCC2 Double Nickase Plasmid (h2) - sc-403531-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

XRCC2 CRISPR Activation Plasmid (h) - sc-403531-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

XRCC2 CRISPR Activation Plasmid (h2) - sc-403531-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

XRCC2 Lentiviral Activation Particles (h) - sc-403531-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

XRCC2 Lentiviral Activation Particles (h2) - sc-403531-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

XRCC2 siRNA (h) - sc-36861 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

XRCC2 shRNA Plasmid (h) - sc-36861-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

XRCC2 shRNA (h) Lentiviral Particles - sc-36861-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

XRCC2 RNAi - H00007516-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU007361 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22984 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22984 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11110 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11110

XRCC2 siRNA (Human) - CRH5137 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

XRCC2 - MBS8230711 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

XRCC2 CRISPR/Cas9 KO Plasmid (h2) - sc-403531-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

XRCC2 HDR Plasmid (h2) - sc-403531-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human XRCC2 (NM_005431.1) - SHH448096 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human XRCC2(NM_005431.1) - SHL138726 from Creative biogene

Category siRNA
Species Reactivities Human

Human XRCC2 siRNA - orb265639 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

XRCC2 shRNA Plasmid (Human) - CHH5137 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

XRCC2 miRNA 3'UTR clone - MiUTR1H-11320 from Creative biogene

Species Reactivities Human
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