| Gene Symbol |
C1qa
|
| Entrez Gene |
12259
|
| Alt Symbol |
AI255395, C1q
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
complement component 1, q subcomponent, alpha polypeptide
|
| Other Description |
complement C1q subcomponent subunit A
|
| Swissprots |
Q9DCM6 P98086
|
| Accessions |
EDL29926 P98086 AK002655 BAB22262 AK136737 BAE23115 AK150771 BAE29837 AK159210 BAE34901 AK159343 BAE35005 BC002086 AAH02086 BC020096 BY318890 BY698724 X58861 CAA41664 NM_007572 NP_031598
|
| Function |
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
|
| Subcellular Location |
Secreted.
|
| Top Pathways |
Complement and coagulation cascades, Systemic lupus erythematosus, Prion diseases, Chagas disease (American trypanosomiasis), Staphylococcus aureus infection
|