Gene Symbol | C1qa |
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Entrez Gene | 12259 |
Alt Symbol | AI255395, C1q |
Species | Mouse |
Gene Type | protein-coding |
Description | complement component 1, q subcomponent, alpha polypeptide |
Other Description | complement C1q subcomponent subunit A |
Swissprots | Q9DCM6 P98086 |
Accessions | EDL29926 P98086 AK002655 BAB22262 AK136737 BAE23115 AK150771 BAE29837 AK159210 BAE34901 AK159343 BAE35005 BC002086 AAH02086 BC020096 BY318890 BY698724 X58861 CAA41664 NM_007572 NP_031598 |
Function | C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. |
Subcellular Location | Secreted. |
Top Pathways | Complement and coagulation cascades, Systemic lupus erythematosus, Prion diseases, Chagas disease (American trypanosomiasis), Staphylococcus aureus infection |
C1q-A CRISPR/Cas9 KO Plasmid (m) - sc-419385 from Santa Cruz Biotechnology
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C1q-A HDR Plasmid (m) - sc-419385-HDR from Santa Cruz Biotechnology
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C1q-A Double Nickase Plasmid (m) - sc-419385-NIC from Santa Cruz Biotechnology
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C1q-A Double Nickase Plasmid (m2) - sc-419385-NIC-2 from Santa Cruz Biotechnology
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C1q-A CRISPR Activation Plasmid (m) - sc-419385-ACT from Santa Cruz Biotechnology
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C1q-A CRISPR Activation Plasmid (m2) - sc-419385-ACT-2 from Santa Cruz Biotechnology
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C1q-A Lentiviral Activation Particles (m) - sc-419385-LAC from Santa Cruz Biotechnology
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C1q-A Lentiviral Activation Particles (m2) - sc-419385-LAC-2 from Santa Cruz Biotechnology
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C1q-A siRNA (m) - sc-44962 from Santa Cruz Biotechnology
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C1q-A shRNA Plasmid (m) - sc-44962-SH from Santa Cruz Biotechnology
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C1q-A shRNA (m) Lentiviral Particles - sc-44962-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU087151 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN27792 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND27792 from Sigma-Aldrich
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C1QA siRNA (Mouse) - CRM0435 from Cohesion Biosciences
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C1QA - MBS8214538 from MyBioSource
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shRNA set against Mouse C1QA (NM_007572.2) - SHH250677 from Creative biogene
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shRNA set against Mouse C1qa(NM_007572.2) - SHG111313 from Creative biogene
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Mouse C1QA siRNA - orb279911 from Biorbyt
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C1QA shRNA Plasmid (Mouse) - CHM0435 from Cohesion Biosciences
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C1QA miRNA 3'UTR clone - MiUTR1M-02350 from Creative biogene
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