| Gene Symbol |
Tnfrsf11a
|
| Entrez Gene |
21934
|
| Alt Symbol |
Ly109, ODFR, OFE, Rank, TRANCE-R, mRANK
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
|
| Other Description |
osteoclast differentiation factor receptor|receptor activator of NF-KB|receptor activator of NF-kappaB|tumor necrosis factor receptor superfamily member 11A
|
| Swissprots |
Q8VCT7 O35305
|
| Accessions |
CAX21651 EDL39871 O35305 AF019046 AAB86810 AK020374 AK042798 AK138990 BC019185 AAH19185 XM_006529381 XP_006529444 NM_009399 NP_033425
|
| Function |
Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. {ECO:0000269|PubMed:20483727, ECO:0000269|PubMed:9878548}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Ubiquitous expression with high levels in trabecular bone, thymus, small intestine, lung, brain and kidney. Weakly expressed in spleen and bone marrow.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Osteoclast differentiation, Rheumatoid arthritis, Prolactin signaling pathway
|