Gene Symbol | Tnfrsf11a |
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Entrez Gene | 21934 |
Alt Symbol | Ly109, ODFR, OFE, Rank, TRANCE-R, mRANK |
Species | Mouse |
Gene Type | protein-coding |
Description | tumor necrosis factor receptor superfamily, member 11a, NFKB activator |
Other Description | osteoclast differentiation factor receptor|receptor activator of NF-KB|receptor activator of NF-kappaB|tumor necrosis factor receptor superfamily member 11A |
Swissprots | Q8VCT7 O35305 |
Accessions | CAX21651 EDL39871 O35305 AF019046 AAB86810 AK020374 AK042798 AK138990 BC019185 AAH19185 XM_006529381 XP_006529444 NM_009399 NP_033425 |
Function | Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. {ECO:0000269|PubMed:20483727, ECO:0000269|PubMed:9878548}. |
Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000305}. |
Tissue Specificity | Ubiquitous expression with high levels in trabecular bone, thymus, small intestine, lung, brain and kidney. Weakly expressed in spleen and bone marrow. |
Top Pathways | Cytokine-cytokine receptor interaction, Osteoclast differentiation, Rheumatoid arthritis, Prolactin signaling pathway |
Recombinant Mouse RANK/TNFRSF11A Fc Chimera, CF - 692-RK-100 from R&D Systems
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Mouse RANk Protein - abx068826 from Abbexa
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sRANK Receptor, Human, Recombinant - 28-10284 from ARP American Research Products
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Recombinant Mouse Tnfrsf11a - Tnfrsf11a-1775M from Creative Biomart
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Recombinant Mouse Tnfrsf11a, Fc-tagged - Tnfrsf11a-472M from Creative Biomart
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Recombinant Mouse Tnfrsf11a, Fc Chimera - Tnfrsf11a-955M from Creative Biomart
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Recombinant Receptor Activator Of Nuclear Factor Kappa B (RANk) - RPC057Mu01 from Cloud-clone
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Recombinant Mouse Tumor necrosis factor receptor superfamily member 11A(Tnfrsf11a) - CSB-YP023968MO CSB-EP023968MO CSB-BP023968MO CSB-MP023968MO from Cusabio
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Recombinant Mouse RANK/TNFRSF11A Fc Chimera Protein, CF - 692-RK from R&D Systems
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Recombinant Mouse TNFRSF11A Protein - TNFRSF11A-17152M from Creative Biomart
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Mouse TNFRSF11A protein - orb371846 from Biorbyt
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TNFRSF11A Recombinant Protein (OPCD06589) - OPCD06589 from Aviva Systems Biology
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RANK Recombinant Protein - 90-276 from ProSci
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Receptor Activator Of Nuclear Factor Kappa B (RANk), Recombinant Protein - MBS2018308 from MyBioSource
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Recombinant Mouse RANK,TNFRSF11A (C-6His) - AP76394 from Signalway Antibody
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