Gene Symbol | Tnfrsf11a |
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Entrez Gene | 21934 |
Alt Symbol | Ly109, ODFR, OFE, Rank, TRANCE-R, mRANK |
Species | Mouse |
Gene Type | protein-coding |
Description | tumor necrosis factor receptor superfamily, member 11a, NFKB activator |
Other Description | osteoclast differentiation factor receptor|receptor activator of NF-KB|receptor activator of NF-kappaB|tumor necrosis factor receptor superfamily member 11A |
Swissprots | Q8VCT7 O35305 |
Accessions | CAX21651 EDL39871 O35305 AF019046 AAB86810 AK020374 AK042798 AK138990 BC019185 AAH19185 XM_006529381 XP_006529444 NM_009399 NP_033425 |
Function | Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. {ECO:0000269|PubMed:20483727, ECO:0000269|PubMed:9878548}. |
Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000305}. |
Tissue Specificity | Ubiquitous expression with high levels in trabecular bone, thymus, small intestine, lung, brain and kidney. Weakly expressed in spleen and bone marrow. |
Top Pathways | Cytokine-cytokine receptor interaction, Osteoclast differentiation, Rheumatoid arthritis, Prolactin signaling pathway |
RANK CRISPR/Cas9 KO Plasmid (m) - sc-423439 from Santa Cruz Biotechnology
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RANK HDR Plasmid (m) - sc-423439-HDR from Santa Cruz Biotechnology
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RANK Double Nickase Plasmid (m) - sc-423439-NIC from Santa Cruz Biotechnology
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RANK Double Nickase Plasmid (m2) - sc-423439-NIC-2 from Santa Cruz Biotechnology
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RANK CRISPR Activation Plasmid (m) - sc-423439-ACT from Santa Cruz Biotechnology
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RANK CRISPR Activation Plasmid (m2) - sc-423439-ACT-2 from Santa Cruz Biotechnology
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RANK Lentiviral Activation Particles (m) - sc-423439-LAC from Santa Cruz Biotechnology
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RANK Lentiviral Activation Particles (m2) - sc-423439-LAC-2 from Santa Cruz Biotechnology
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RANK siRNA (m) - sc-42961 from Santa Cruz Biotechnology
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RANK shRNA Plasmid (m) - sc-42961-SH from Santa Cruz Biotechnology
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RANK shRNA (m) Lentiviral Particles - sc-42961-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN43225 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND43225 from Sigma-Aldrich
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TNFRSF11A siRNA (Mouse) - CRM4181 from Cohesion Biosciences
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TNFRSF11A - MBS8203878 from MyBioSource
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shRNA set against Mouse TNFRSF11A (NM_009399.3) - SHH431876 from Creative biogene
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TNFRSF11A shRNA Plasmid (Mouse) - CHM4181 from Cohesion Biosciences
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TNFRSF11A miRNA 3'UTR clone - MiUTR1M-11985 from Creative biogene
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