CACNA1B

Gene Symbol CACNA1B
Entrez Gene 774
Alt Symbol BIII, CACNL1A5, CACNN, Cav2.2, DYT23
Species Human
Gene Type protein-coding
Description calcium channel, voltage-dependent, N type, alpha 1B subunit
Other Description Cav2.2 voltage-gated Ca2+ channel|brain calcium channel III|calcium channel alpha12.2 subunit|calcium channel, L type, alpha-1 polypeptide|calcium channel, N type|calcium channel, voltage-dependent, L type, alpha 1B subunit|calcium channel, voltage-dependent, alpha 1B subunit, N type|voltage-dependent N-type calcium channel subunit alpha-1B|voltage-gated calcium channel alpha subunit Cav2.2|voltage-gated calcium channel subunit alpha Cav2.2
Swissprots B1AQK5 Q00975
Accessions AAC51138 AAG13642 AAG13643 AAG13644 AAG13645 AAG13646 AAG13647 AAG13648 AAG13650 AAG14396 AAG14397 AAG14398 CAJ41866 EAW88415 EAW88416 EAW88417 EAW88418 Q00975 AB209467 BAD92704 AY429522 AY429523 BC033060 M94172 AAA51897 M94173 AAA51898 XM_011518990 XP_011517292 XM_011518991 XP_011517293 XM_011518992 XP_011517294 XM_011518993 XP_011517295 XM_011518994 XP_011517296 XM_011518995 XP_011517297 XM_011518996 XP_011517298 XM_011518997 XP_011517299 NM_000718 NP_000709 NM_001243812 NP_001230741
Function Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin- IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta.
Top Pathways GABAergic synapse, Retrograde endocannabinoid signaling, Nicotine addiction, Morphine addiction, Dopaminergic synapse

Recombinant Calcium Channel, Voltage Dependent, N-Type, Alpha 1B Subunit (CACNa1B) - RPF240Hu01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Human

Recombinant Calcium Channel, Voltage Dependent, N-Type, Alpha 1B Subunit (CACNa1B) - RPF240Mu01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Mouse

Recombinant Calcium Channel, Voltage Dependent, N-Type, Alpha 1B Subunit (CACNa1B) - RPF240Mu02 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Mouse

Recombinant Calcium Channel, Voltage Dependent, N-Type, Alpha 1B Subunit (CACNa1B) - RPF240Hu01 from Cloud-clone

Category Protein
Source E.coli
Species Human

Cav2.2 Recombinant Protein Antigen - NBP1-91744PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

CACNA1B Peptide, Human - M34GP02253H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human
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