| Gene Symbol |
CACNA1B
|
| Entrez Gene |
774
|
| Alt Symbol |
BIII, CACNL1A5, CACNN, Cav2.2, DYT23
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
calcium channel, voltage-dependent, N type, alpha 1B subunit
|
| Other Description |
Cav2.2 voltage-gated Ca2+ channel|brain calcium channel III|calcium channel alpha12.2 subunit|calcium channel, L type, alpha-1 polypeptide|calcium channel, N type|calcium channel, voltage-dependent, L type, alpha 1B subunit|calcium channel, voltage-dependent, alpha 1B subunit, N type|voltage-dependent N-type calcium channel subunit alpha-1B|voltage-gated calcium channel alpha subunit Cav2.2|voltage-gated calcium channel subunit alpha Cav2.2
|
| Swissprots |
B1AQK5 Q00975
|
| Accessions |
AAC51138 AAG13642 AAG13643 AAG13644 AAG13645 AAG13646 AAG13647 AAG13648 AAG13650 AAG14396 AAG14397 AAG14398 CAJ41866 EAW88415 EAW88416 EAW88417 EAW88418 Q00975 AB209467 BAD92704 AY429522 AY429523 BC033060 M94172 AAA51897 M94173 AAA51898 XM_011518990 XP_011517292 XM_011518991 XP_011517293 XM_011518992 XP_011517294 XM_011518993 XP_011517295 XM_011518994 XP_011517296 XM_011518995 XP_011517297 XM_011518996 XP_011517298 XM_011518997 XP_011517299 NM_000718 NP_000709 NM_001243812 NP_001230741
|
| Function |
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin- IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta.
|
| Top Pathways |
GABAergic synapse, Retrograde endocannabinoid signaling, Nicotine addiction, Morphine addiction, Dopaminergic synapse
|