Gene Symbol | Ebi3 |
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Entrez Gene | 50498 |
Alt Symbol | EBI-3, IL-27 |
Species | Mouse |
Gene Type | protein-coding |
Description | Epstein-Barr virus induced gene 3 |
Other Description | IL-27 subunit beta|IL-27B|epstein-Barr virus-induced gene 3 protein homolog|interleukin-27 subunit beta |
Swissprots | O35228 |
Accessions | EDL23692 EDL23693 O35228 AF013114 AAB67115 AK155023 BAE32996 AK155903 BAE33494 AW495532 BC008209 AAH08209 BI134394 BY134465 CX240802 XM_006524599 XP_006524662 NM_015766 NP_056581 |
Function | Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T- helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. |
Subcellular Location | Secreted {ECO:0000250}. |
Ebi3 CRISPR/Cas9 KO Plasmid (m) - sc-424448 from Santa Cruz Biotechnology
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Ebi3 HDR Plasmid (m) - sc-424448-HDR from Santa Cruz Biotechnology
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Ebi3 Double Nickase Plasmid (m) - sc-424448-NIC from Santa Cruz Biotechnology
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Ebi3 Double Nickase Plasmid (m2) - sc-424448-NIC-2 from Santa Cruz Biotechnology
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Ebi3 CRISPR Activation Plasmid (m) - sc-424448-ACT from Santa Cruz Biotechnology
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Ebi3 CRISPR Activation Plasmid (m2) - sc-424448-ACT-2 from Santa Cruz Biotechnology
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Ebi3 Lentiviral Activation Particles (m) - sc-424448-LAC from Santa Cruz Biotechnology
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Ebi3 Lentiviral Activation Particles (m2) - sc-424448-LAC-2 from Santa Cruz Biotechnology
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Ebi3 siRNA (m) - sc-39411 from Santa Cruz Biotechnology
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Ebi3 shRNA Plasmid (m) - sc-39411-SH from Santa Cruz Biotechnology
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Ebi3 shRNA (m) Lentiviral Particles - sc-39411-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU059781 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN30400 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND30400 from Sigma-Aldrich
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EBI3 siRNA (Mouse) - CRM5104 from Cohesion Biosciences
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EBI3 - MBS8240481 from MyBioSource
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shRNA set against Mouse EBI3 (NM_015766.2) - SHH282777 from Creative biogene
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shRNA set against Mouse Ebi3(NM_015766.2) - SHH022853 from Creative biogene
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Mouse EBI3 siRNA - orb284580 from Biorbyt
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EBI3 shRNA Plasmid (Mouse) - CHM5104 from Cohesion Biosciences
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EBI3 miRNA 3'UTR clone - MiUTR1M-04147 from Creative biogene
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