GRIA1

Gene Symbol	GRIA1
Entrez Gene	2890
Alt Symbol	GLUH1, GLUR1, GLURA, GluA1, HBGR1
Species	Human
Gene Type	protein-coding
Description	glutamate receptor, ionotropic, AMPA 1
Other Description	AMPA 1|AMPA-selective glutamate receptor 1|gluR-1|gluR-A|gluR-K1|glutamate receptor 1
Swissprots	D3DQI4 Q2NKM6 E7ESV8 B7Z9G9 P42261 B7Z2W8 B7Z3F6 B7Z2S0
Accessions	EAW61649 EAW61650 EAW61651 P42261 AB209094 BAD92331 AK289565 BAF82254 AK294011 BAH11647 AK294773 BAH11879 AK295039 BAH11956 AK295184 BAH12004 AK295827 BAH12192 AK310189 AK315934 BAH14305 AL120214 BC111734 AAI11735 DC335107 FJ947077 ACR45954 FJ947078 ACR45955 M64752 AAA58613 M81886 AAA58395 X58633 CAA41491 Z70220 XM_011537635 XP_011535937 XR_427776 NM_000827 NP_000818 NM_001114183 NP_001107655 NM_001258019 NP_001244948 NM_001258020 NP_001244949 NM_001258021 NP_001244950 NM_001258022 NP_001244951 NM_001258023 NP_001244952 NR_047578
Function	Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. {ECO:0000269|PubMed:20805473, ECO:0000269|PubMed:21172611}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:23739980}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000269|PubMed:23739980}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. {ECO:0000250}.
Tissue Specificity	Widely expressed in brain.
Top Pathways	cAMP signaling pathway, Circadian entrainment, Retrograde endocannabinoid signaling, Nicotine addiction, Amphetamine addiction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat GRIA1 / GLUR1 ELISA Kit (Cell-Based ELISA) - LS-F2017 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 15.63-1000 pg/ml

Mouse/Human/Rat Phospho-GRIA1 / GLUR1 (Ser863) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1518 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 15.63-1000 pg/ml

Rat GRIA1 / GLUR1 ELISA Kit (Sandwich ELISA) - LS-F7442 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 6.1 pg/ml Range 15.63-1000 pg/ml

Human GRIA1 / GLUR1 ELISA Kit (Sandwich ELISA) - LS-F8850 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.056 ng/ml Range 15.63-1000 pg/ml

Human GRIA1 ELISA Kit - abx151738 from Abbexa Category ELISA Kit Sensitivity 0.056 ng/ml Range 0.156 ng/ml - 10 ng/ml

Anti-Glutamate Receptor 1, Human, ELISA Kit - E01A0633 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 1.0ng/ml Range 5-100ng/ml

Glutamate receptor 1 (GRIA1), Human, ELISA Kit - CSB-EL009898HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 5.86 pg/ml Range 23.44 pg/ml-1500 pg/ml

Glutamate receptor 1 (GRIA1), Human, ELISA Kit - E01G0390 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Glutamate Receptor, Ionotropic, AMPA 1 (GRIA1), Human, ELISA Kit - SEE801Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.056ng/mL Range 0.156-10ng/mL

Glutamate Receptor, Ionotropic, AMPA 1, ELISA Kit - MBS081473 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Glutamate Receptor, Ionotropic, AMPA 1, ELISA Kit - MBS049484 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Glutamate Receptor, Ionotropic, AMPA 1, ELISA Kit - MBS055893 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Glutamate Receptor, Ionotropic, AMPA 1, ELISA Kit - MBS076633 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

glutamate receptor, ionotropic, AMPA 1, ELISA Kit - MBS945568 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human GRIA1 is typically less than 5.86 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 23.44 pg/ml -1500 pg/ml.

Glutamate Receptor, Ionotropic, AMPA 1, ELISA Kit - MBS088496 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Glutamate Receptor, Ionotropic, AMPA 1, ELISA Kit - MBS087773 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Glutamate Receptor, Ionotropic, AMPA 1, ELISA Kit - MBS095476 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Glutamate Receptor, Ionotropic, AMPA 1 (GRIA1), ELISA Kit - MBS2021910 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.056ng/mL. Range 0.156-10ng/mL

Glutamate Receptor, Ionotropic, AMPA 1 (GRIA1), ELISA Kit - MBS2023128 from MyBioSource Category ELISA Kit Prices $405.00, $605.00, $820.00, $3,375.00, $6,125.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of rat GRIA1 is typically less than 6.1pg/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration. Range 15.6-1,000pg/mL

GRIA1, ELISA Kit - MBS2515953 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 46.875pg/mL Range 78.125-5000pg/mL

GluR1 Colorimetric Cell-Based ELISA Kit - CB5295 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

GluR1 (Phospho-Ser863) Colorimetric Cell-Based ELISA Kit - CBP1564 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

GluR1 (Phospho-Ser849) Colorimetric Cell-Based ELISA - CBP1877 from Assay Biotechnology Category ELISA Kit Prices $450.00 Sizes 2 x 96 tests Range > 5000 Cells

Anti Glutamate Receptor 1, ELISA Kit - MBS755645 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/mL

Anti-Glutamate Receptor 1, ELISA Kit - MBS754618 from MyBioSource Category ELISA Kit Prices $470.00, $675.00 Sizes 48 strip wells, 96 strip wells

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