GRIA1

Gene Symbol	GRIA1
Entrez Gene	2890
Alt Symbol	GLUH1, GLUR1, GLURA, GluA1, HBGR1
Species	Human
Gene Type	protein-coding
Description	glutamate receptor, ionotropic, AMPA 1
Other Description	AMPA 1|AMPA-selective glutamate receptor 1|gluR-1|gluR-A|gluR-K1|glutamate receptor 1
Swissprots	D3DQI4 Q2NKM6 E7ESV8 B7Z9G9 P42261 B7Z2W8 B7Z3F6 B7Z2S0
Accessions	EAW61649 EAW61650 EAW61651 P42261 AB209094 BAD92331 AK289565 BAF82254 AK294011 BAH11647 AK294773 BAH11879 AK295039 BAH11956 AK295184 BAH12004 AK295827 BAH12192 AK310189 AK315934 BAH14305 AL120214 BC111734 AAI11735 DC335107 FJ947077 ACR45954 FJ947078 ACR45955 M64752 AAA58613 M81886 AAA58395 X58633 CAA41491 Z70220 XM_011537635 XP_011535937 XR_427776 NM_000827 NP_000818 NM_001114183 NP_001107655 NM_001258019 NP_001244948 NM_001258020 NP_001244949 NM_001258021 NP_001244950 NM_001258022 NP_001244951 NM_001258023 NP_001244952 NR_047578
Function	Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. {ECO:0000269|PubMed:20805473, ECO:0000269|PubMed:21172611}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:23739980}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000269|PubMed:23739980}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. {ECO:0000250}.
Tissue Specificity	Widely expressed in brain.
Top Pathways	cAMP signaling pathway, Circadian entrainment, Retrograde endocannabinoid signaling, Nicotine addiction, Amphetamine addiction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Glutamate Receptor 1 (AMPA subtype) peptide - ab28424 from Abcam Category Peptide

Human Glutamate Receptor 1 (AMPA subtype) protein fragment - ab112297 from Abcam Category Protein Source Wheat germ Species Human

Mouse Glutamate Receptor 1 (AMPA subtype) (phospho T840) peptide - ab12399 from Abcam Category Peptide

Mouse Glutamate Receptor 1 (AMPA subtype) (unmodified ) peptide - ab12434 from Abcam Category Peptide

GRIA1 / GLUR1 Antibody Blocking Peptide - LS-E27691 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GRIA1 / GLUR1 Antibody Blocking Peptide - LS-E13509 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human GluR1 Protein - H00002890-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

GluR1 blocking peptide - GTX89200-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

GRIA1 Blocking Peptide - 33R-1690 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

GLUR1 (phospho-Ser849) Blocking Peptide - abx062694 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken, Monkey

Glutamate Receptor 1 (Ampa Subtype) Peptide - AC21-2507-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Glutamate receptor 1 / GLUR1 - H00002890-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Glutamate receptor 1 / GLUR1 - H00002890-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Glutamate receptor 1 / GLUR1 control peptide - AP10082CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

GRIA1 Peptide - 42-403P from ProSci Category Peptide Species Human, Mouse, Rat

Recombinant Human GRIA1 - GRIA1-29069TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Glutamate Receptor, Ionotropic, AMPA 1 (GRIA1) - RPE801Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Glutamate Receptor, Ionotropic, AMPA 1 (GRIA1) - RPE801Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

GLUR1 (pS849) Blocking Peptide - CBP1500 from Cohesion Biosciences Category Peptide Prices $150.00, $450.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Chicken, Monkey

GluR1 (L844) Peptide - BS3656P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

GluR1 (S857) Peptide - BS3657P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

p-GluR1 (S849) Peptide - BS4792P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

p-GluR-1 (S863) Peptide - BS4793P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Glutamate Receptor, Ionotropic, AMPA 1 (GRIA1) - RPE801Hu01 from Cloud-clone Category Protein Source E.coli Species Human

GluR1(phospho-Ser849) antibody blocking peptide - 51261 from Signalway Antibody Category Peptide Prices $70.00 Sizes 100 µl

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