GRIA1

Gene Symbol GRIA1
Entrez Gene 2890
Alt Symbol GLUH1, GLUR1, GLURA, GluA1, HBGR1
Species Human
Gene Type protein-coding
Description glutamate receptor, ionotropic, AMPA 1
Other Description AMPA 1|AMPA-selective glutamate receptor 1|gluR-1|gluR-A|gluR-K1|glutamate receptor 1
Swissprots D3DQI4 Q2NKM6 E7ESV8 B7Z9G9 P42261 B7Z2W8 B7Z3F6 B7Z2S0
Accessions EAW61649 EAW61650 EAW61651 P42261 AB209094 BAD92331 AK289565 BAF82254 AK294011 BAH11647 AK294773 BAH11879 AK295039 BAH11956 AK295184 BAH12004 AK295827 BAH12192 AK310189 AK315934 BAH14305 AL120214 BC111734 AAI11735 DC335107 FJ947077 ACR45954 FJ947078 ACR45955 M64752 AAA58613 M81886 AAA58395 X58633 CAA41491 Z70220 XM_011537635 XP_011535937 XR_427776 NM_000827 NP_000818 NM_001114183 NP_001107655 NM_001258019 NP_001244948 NM_001258020 NP_001244949 NM_001258021 NP_001244950 NM_001258022 NP_001244951 NM_001258023 NP_001244952 NR_047578
Function Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. {ECO:0000269|PubMed:20805473, ECO:0000269|PubMed:21172611}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:23739980}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000269|PubMed:23739980}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. {ECO:0000250}.
Tissue Specificity Widely expressed in brain.
Top Pathways cAMP signaling pathway, Circadian entrainment, Retrograde endocannabinoid signaling, Nicotine addiction, Amphetamine addiction

GluR-1 CRISPR/Cas9 KO Plasmid (h) - sc-416424 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GluR-1 HDR Plasmid (h) - sc-416424-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GluR-1 Double Nickase Plasmid (h) - sc-416424-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GluR-1 Double Nickase Plasmid (h2) - sc-416424-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GluR-1 CRISPR Activation Plasmid (h) - sc-416424-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GluR-1 CRISPR Activation Plasmid (h2) - sc-416424-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GluR-1 Lentiviral Activation Particles (h) - sc-416424-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GluR-1 Lentiviral Activation Particles (h2) - sc-416424-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GluR-1 siRNA (h) - sc-35485 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GluR-1 shRNA Plasmid (h) - sc-35485-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GluR-1 shRNA (h) Lentiviral Particles - sc-35485-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GluR1 RNAi - H00002890-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU151461 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9675 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9675 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03232 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03232

GRIA1 siRNA (Human) - CRH1944 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GluR-1 siRNA (r) - sc-270586 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Rat

GluR-1 shRNA Plasmid (r) - sc-270586-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Rat

GluR-1 shRNA (r) Lentiviral Particles - sc-270586-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Rat

GRIA1 - MBS8236486 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human GRIA1 (NM_000827.3) - SHH307730 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human GRIA1(NM_000827.3) - SHH103727 from Creative biogene

Category siRNA
Species Reactivities Human

Human GRIA1 siRNA - orb262446 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GRIA1 shRNA Plasmid (Human) - CHH1944 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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