PFN1

Gene Symbol	PFN1
Entrez Gene	5216
Alt Symbol	ALS18
Species	Human
Gene Type	protein-coding
Description	profilin 1
Other Description	epididymis tissue protein Li 184a|profilin I|profilin-1
Swissprots	Q53Y44 P07737
Accessions	EAW90381 EAW90382 EAW90383 EAW90384 P07737 AA358044 AK312168 BAG35102 AL525538 BC002475 AAH02475 BC006768 AAH06768 BC013439 AAH13439 BC015164 AAH15164 BC057828 AAH57828 BM850671 BT007001 AAP35647 CR407670 CAG28598 D28377 BAA05743 DQ891100 ABM82026 DQ894282 ABM85208 GU727630 ADU87632 J03191 AAA36486 NM_005022 NP_005013
Function	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. {ECO:0000269|PubMed:18573880}.
Subcellular Location	Cytoplasm, cytoskeleton.
Tissue Specificity	Expressed in epididymis (at protein level). {ECO:0000269|PubMed:20736409}.
Top Pathways	Salmonella infection, Rap1 signaling pathway, Regulation of actin cytoskeleton

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Profilin 1 full length protein - ab87760 from Abcam Category Protein Source E. coli Species Human

Human Profilin 1 full length protein - ab190410 from Abcam Category Protein Source E. coli Species Human

Human Profilin 1 peptide - ab104286 from Abcam Category Peptide

PFN1 / Profilin 1 Antibody Blocking Peptide - LS-E17465 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Profilin 1 Blocking Peptide - NBP1-19344PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

Profilin 1 Recombinant Protein - H00005216-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Profilin 1 Recombinant Protein - H00005216-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Profilin 1 Protein - NBP1-30215 from Novus Biologicals Category Protein Prices $249.00 Sizes 100 µg Species Human

PFN1-Antibody-Center-Blocking-Peptide - BP2837c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PFN1-Antibody-C-term-Blocking-Peptide - BP2837b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant human Profilin-1 (OPCA00542) - OPCA00542 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

PFN1 Protein (OPPA01417) - OPPA01417 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg Source E. Coli

Human PFN1 protein - orb245203 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Profilin 1 Blocking Peptide - 33R-1234 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Profilin 1 protein - 30R-1376 from Fitzgerald Category Protein Prices $250.00 Sizes 100 µg Source E.coli

Human Profilin 1 Protein - abx068675 from Abbexa Category Protein Source E.coli Species Human

Profilin-1 / PFN1 (1-140) - AR09259PU-L from Acris Antibodies Category Protein Prices $585.00 Sizes 500 µg Source E. coli Species Human

Profilin-1 / PFN1 (1-140) - AR09259PU-N from Acris Antibodies Category Protein Prices $270.00 Sizes 100 µg Source E. coli Species Human

Profilin-1 / PFN1 - H00005216-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Profilin-1 / PFN1 - H00005216-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Profilin-1 / PFN1 - H00005216-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

Profilin-1 / PFN1 - H00005216-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Profilin-1 / PFN1 - H00005216-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Profilin-1, Human Recombinant - 228-13103-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human Profilin-1 - 228-13103-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Search more