PFN1

Gene Symbol PFN1
Entrez Gene 5216
Alt Symbol ALS18
Species Human
Gene Type protein-coding
Description profilin 1
Other Description epididymis tissue protein Li 184a|profilin I|profilin-1
Swissprots Q53Y44 P07737
Accessions EAW90381 EAW90382 EAW90383 EAW90384 P07737 AA358044 AK312168 BAG35102 AL525538 BC002475 AAH02475 BC006768 AAH06768 BC013439 AAH13439 BC015164 AAH15164 BC057828 AAH57828 BM850671 BT007001 AAP35647 CR407670 CAG28598 D28377 BAA05743 DQ891100 ABM82026 DQ894282 ABM85208 GU727630 ADU87632 J03191 AAA36486 NM_005022 NP_005013
Function Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. {ECO:0000269|PubMed:18573880}.
Subcellular Location Cytoplasm, cytoskeleton.
Tissue Specificity Expressed in epididymis (at protein level). {ECO:0000269|PubMed:20736409}.
Top Pathways Salmonella infection, Rap1 signaling pathway, Regulation of actin cytoskeleton

Profilin-1 CRISPR/Cas9 KO Plasmid (h) - sc-402070 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Profilin-1 HDR Plasmid (h) - sc-402070-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Profilin-1 Double Nickase Plasmid (h) - sc-402070-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Profilin-1 Double Nickase Plasmid (h2) - sc-402070-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Profilin-1 CRISPR Activation Plasmid (h) - sc-402070-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Profilin-1 CRISPR Activation Plasmid (h2) - sc-402070-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Profilin-1 Lentiviral Activation Particles (h) - sc-402070-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Profilin-1 Lentiviral Activation Particles (h2) - sc-402070-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Profilin-1 siRNA (h) - sc-36316 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Profilin-1 shRNA Plasmid (h) - sc-36316-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Profilin-1 shRNA (h) Lentiviral Particles - sc-36316-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Profilin-1/2 siRNA (h) - sc-44045 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Profilin-1/2 shRNA Plasmid (h) - sc-44045-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Profilin-1/2 shRNA (h) Lentiviral Particles - sc-44045-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Profilin 1 RNAi - H00005216-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU106911 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16661 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16661 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00955 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00955

PFN1 siRNA (Human) - CRH3485 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PFN1 (NM_005022.3) - SHH373992 from Creative biogene

Category siRNA
Species Reactivities Human

Human PFN1 siRNA - orb263987 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PFN1 shRNA Plasmid (Human) - CHH3485 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PFN1 miRNA 3'UTR clone - MiUTR3H-01825 from Creative biogene

Species Reactivities Human
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