| Gene Symbol |
Stam2
|
| Entrez Gene |
56324
|
| Alt Symbol |
1200004O12Rik, 5730456G07Rik, BB145015, Hbp
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
|
| Other Description |
Hrs binding protein|STAM-2|hrs-binding protein|signal transducing adapter molecule 2
|
| Swissprots |
Q8C8Y4 A2AU00 O88811
|
| Accessions |
AAX90618 CAX15926 EDL26912 EDL26913 O88811 AB012611 BAA33547 AK004604 BAB23403 AK017668 AK035789 AK044230 BAC31830 AK078244 AK159699 BAE35299 AK168729 BAE40570 AK188839 AK214650 BC013818 AAH13818 DQ141211 AAZ82831 XM_006498198 XP_006498261 NM_019667 NP_062641
|
| Function |
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:10651905, ECO:0000269|PubMed:12551915}. Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitously expressed, with highest levels in testis. {ECO:0000269|PubMed:10651905}.
|
| Top Pathways |
Jak-STAT signaling pathway, Endocytosis
|