Gene Symbol | Stam2 |
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Entrez Gene | 56324 |
Alt Symbol | 1200004O12Rik, 5730456G07Rik, BB145015, Hbp |
Species | Mouse |
Gene Type | protein-coding |
Description | signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 |
Other Description | Hrs binding protein|STAM-2|hrs-binding protein|signal transducing adapter molecule 2 |
Swissprots | Q8C8Y4 A2AU00 O88811 |
Accessions | AAX90618 CAX15926 EDL26912 EDL26913 O88811 AB012611 BAA33547 AK004604 BAB23403 AK017668 AK035789 AK044230 BAC31830 AK078244 AK159699 BAE35299 AK168729 BAE40570 AK188839 AK214650 BC013818 AAH13818 DQ141211 AAZ82831 XM_006498198 XP_006498261 NM_019667 NP_062641 |
Function | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:10651905, ECO:0000269|PubMed:12551915}. Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. |
Tissue Specificity | Ubiquitously expressed, with highest levels in testis. {ECO:0000269|PubMed:10651905}. |
Top Pathways | Jak-STAT signaling pathway, Endocytosis |
STAM2 CRISPR/Cas9 KO Plasmid (m) - sc-425090 from Santa Cruz Biotechnology
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STAM2 HDR Plasmid (m) - sc-425090-HDR from Santa Cruz Biotechnology
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STAM2 Double Nickase Plasmid (m) - sc-425090-NIC from Santa Cruz Biotechnology
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STAM2 Double Nickase Plasmid (m2) - sc-425090-NIC-2 from Santa Cruz Biotechnology
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STAM2 CRISPR Activation Plasmid (m) - sc-425090-ACT from Santa Cruz Biotechnology
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STAM2 CRISPR Activation Plasmid (m2) - sc-425090-ACT-2 from Santa Cruz Biotechnology
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STAM2 Lentiviral Activation Particles (m) - sc-425090-LAC from Santa Cruz Biotechnology
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STAM2 Lentiviral Activation Particles (m2) - sc-425090-LAC-2 from Santa Cruz Biotechnology
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STAM2 siRNA (m) - sc-76585 from Santa Cruz Biotechnology
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STAM2 shRNA Plasmid (m) - sc-76585-SH from Santa Cruz Biotechnology
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STAM2 shRNA (m) Lentiviral Particles - sc-76585-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN42148 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND42148 from Sigma-Aldrich
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STAM2 siRNA (Mouse) - CRM5725 from Cohesion Biosciences
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STAM2 - MBS8225396 from MyBioSource
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shRNA set against Mouse STAM2 (NM_019667.2) - SHH419200 from Creative biogene
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shRNA set against Mouse Stam2(NM_019667.2) - SHL039774 from Creative biogene
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STAM2 shRNA Plasmid (Mouse) - CHM5725 from Cohesion Biosciences
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STAM2 miRNA 3'UTR clone - MiUTR1M-11300 from Creative biogene
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