PDXP

Gene Symbol PDXP
Entrez Gene 57026
Alt Symbol CIN, PLP, dJ37E16.5
Species Human
Gene Type protein-coding
Description pyridoxal (pyridoxine, vitamin B6) phosphatase
Other Description PLP phosphatase|chronophin|pyridoxal phosphate phosphatase
Swissprots Q9UGY2 Q96GD0
Accessions EAW60176 EAW60177 Q96GD0 AK057265 AY125047 AAM94358 BC000320 AAH00320 BC009756 AAH09756 BC012832 BC018844 BC064922 AAH64922 NM_020315 NP_064711
Function Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP. {ECO:0000269|PubMed:14522954, ECO:0000269|PubMed:15580268}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:15580268}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15580268}. Cell projection, ruffle membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Diffusely distributed throughout the cytosol during pro-metaphase and metaphase. Detected at the dynamic cell poles during telophase. Detected at the cleavage furrow and contractile ring during cytokinesis. Transiently detected at the plasma membrane in late stages of cytokinesis. Detected at the midbody.
Tissue Specificity Ubiquitous. Highly expressed in all the regions of central nerve system except the spinal cord. Also expressed at high level in liver and testis. In fetus, it is weakly expressed in all organs except brain. {ECO:0000269|PubMed:14522954, ECO:0000269|PubMed:15580268}.
Top Pathways Vitamin B6 metabolism

Chronophin/PDXP (C85E3) Rabbit mAb - 4686 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C85E3
Western blot analysis of extracts from various cell types using Chronophin/PDXP (C85E3) Rabbit mAb.

pyridoxal phosphatase (D-12) - sc-271214 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
pyridoxal phosphatase (D-12): sc-271214. Western blot analysis of pyridoxal phosphatase expression in non-transfected: sc-117752 (A) and human pyridoxal phosphatase transfected: sc-117114 (B) 293T whole cell lysates.

pyridoxal phosphatase (F-2) - sc-271379 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
pyridoxal phosphatase (F-2): sc-271379. Western blot analysis of pyridoxal phosphatase expression in non-transfected: sc-117752 (A) and human pyridoxal phosphatase transfected: sc-117114 (B) 293T whole cell lysates.

pyridoxal phosphatase (H-5) - sc-398850 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
pyridoxal phosphatase (H-5): sc-398850. Western blot analysis of pyridoxal phosphatase expression in non-transfected: sc-117752 (A) and human pyridoxal phosphatase transfected: sc-117114 (B) 293T whole cell lysates and mouse brain tissue extract (C).

pyridoxal phosphatase (C-15) - sc-48072 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
pyridoxal phosphatase (C-15): sc-48072. Western blot analysis of pyridoxal phosphatase expression in non-transfected 293T: sc-117752 (A), human pyridoxal phosphatase transfected 293T: sc-117114 (B) and Hep G2 (C) whole cell lysates.

pyridoxal phosphatase (B-3) - sc-271021 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
pyridoxal phosphatase (B-3): sc-271021. Western blot analysis of pyridoxal phosphatase expression in non-transfected: sc-117752 (A) and human pyridoxal phosphatase transfected: sc-117114 (B) 293T whole cell lysates.

pyridoxal phosphatase (A-11) - sc-271073 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
pyridoxal phosphatase (A-11): sc-271073. Western blot analysis of pyridoxal phosphatase expression in non-transfected: sc-117752 (A) and human pyridoxal phosphatase transfected: sc-117114 (B) 293T whole cell lysates.

pyridoxal phosphatase (C-12) - sc-48071 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
pyridoxal phosphatase (C-12): sc-48071. Western blot analysis of pyridoxal phosphatase expression in non-transfected: sc-117752 (A) and human pyridoxal phosphatase transfected: sc-117114 (B) 293T whole cell lysates.

Anti-PDXP antibody - ab86422 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PDXP antibody (ab86422) at 1 µg/ml + Jurkat cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG diluted at 1/50000 dilution

Anti-PDXP / Pyridoxal Phosphatase Antibody (aa179-228) - LS-C102724 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PDXP antibody LS-C102724 Western blot of Jurkat lysate.

Anti-PDXP / Pyridoxal Phosphatase Antibody (aa58-107) - LS-C201696 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human HT1080 . PDXP antibody dilution 1.0 ug/ml.

Anti-PDXP / Pyridoxal Phosphatase Antibody (aa275-286) IHC-plus™ - LS-B10464 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Human, Tonsil: Foramlin-Fixed Paraffin-Embedded (FFPE)

PDXP Antibody - NBP1-56888 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PDXP Antibody [NBP1-56888] - Titration: 0.2-1 ug/ml, Positive Control: Jurkat cell lysate.

PDXP Antibody - NBP1-85178 from Novus Biologicals

Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: PDXP Antibody [NBP1-85178] - Staining of human cell line U-251MG shows positivity in nucleus but not nucleoli & cytoplasm.

PDXP Antibody - NBP2-27461 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: PDXP Antibody [NBP2-27461] - 0.1 ug/ml staining of Mouse (A) and Rat (B) Brain lysates (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-PDXP antibody produced in rabbit - SAB2103134 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PDXP, antibody produced in rabbit: <B>Cat. No. SAB2103134</B>: Immunoblotting analysis of PDXP in Jurkat cell lysate with PDXP anitbody at 1 μg/mL.

Anti-PDXP antibody produced in rabbit - HPA001099 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PDXP: <B>Cat. No. HPA001099</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human duodenal tissue showing cytoplasmic staining of glandular cells.

Anti-PDXP (C-terminal) antibody produced in goat - SAB2501870 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PDXP (C-terminal): <B>Cat. No. SAB2501870</B>: (0.1 μg/mL) staining of Human Heart lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

PDXP Antibody - N-terminal region (ARP57384_P050) - ARP57384_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PDXP antibody - middle region (ARP57385_P050) - ARP57385_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PDXP-Antibody-C-Term - AF3387a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF3387a (0.1 µg/ml) staining of Human Heart lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

DENTT / CDA1 antibody, C-term - GTX88198 from GeneTex

Prices $319.00
Sizes 100 μg
Host Goat
Clonality Polyclonal
Anti-DENTT / CDA1 antibody, C-term used in IHC (Formalin-fixed paraffin-embedded sections). GTX88198

Goat anti-PDXP -C-terminal region Antibody (OAEB02716) - OAEB02716 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

PLP antibody - 10R-7784 from Fitzgerald

Prices $495.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone NYRPLP

PDXP antibody - 70R-4378 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
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