PDXP

Gene Symbol PDXP
Entrez Gene 57026
Alt Symbol CIN, PLP, dJ37E16.5
Species Human
Gene Type protein-coding
Description pyridoxal (pyridoxine, vitamin B6) phosphatase
Other Description PLP phosphatase|chronophin|pyridoxal phosphate phosphatase
Swissprots Q9UGY2 Q96GD0
Accessions EAW60176 EAW60177 Q96GD0 AK057265 AY125047 AAM94358 BC000320 AAH00320 BC009756 AAH09756 BC012832 BC018844 BC064922 AAH64922 NM_020315 NP_064711
Function Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP. {ECO:0000269|PubMed:14522954, ECO:0000269|PubMed:15580268}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:15580268}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15580268}. Cell projection, ruffle membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Diffusely distributed throughout the cytosol during pro-metaphase and metaphase. Detected at the dynamic cell poles during telophase. Detected at the cleavage furrow and contractile ring during cytokinesis. Transiently detected at the plasma membrane in late stages of cytokinesis. Detected at the midbody.
Tissue Specificity Ubiquitous. Highly expressed in all the regions of central nerve system except the spinal cord. Also expressed at high level in liver and testis. In fetus, it is weakly expressed in all organs except brain. {ECO:0000269|PubMed:14522954, ECO:0000269|PubMed:15580268}.
Top Pathways Vitamin B6 metabolism

pyridoxal phosphatase (h): 293T Lysate - sc-117114 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

Panoply™ Human PDXP Knockdown Stable Cell Line - CSC-DC011561 from Creative biogene

Category Cell Line
Species Human
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