PDXP

Gene Symbol PDXP
Entrez Gene 57026
Alt Symbol CIN, PLP, dJ37E16.5
Species Human
Gene Type protein-coding
Description pyridoxal (pyridoxine, vitamin B6) phosphatase
Other Description PLP phosphatase|chronophin|pyridoxal phosphate phosphatase
Swissprots Q9UGY2 Q96GD0
Accessions EAW60176 EAW60177 Q96GD0 AK057265 AY125047 AAM94358 BC000320 AAH00320 BC009756 AAH09756 BC012832 BC018844 BC064922 AAH64922 NM_020315 NP_064711
Function Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP. {ECO:0000269|PubMed:14522954, ECO:0000269|PubMed:15580268}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:15580268}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15580268}. Cell projection, ruffle membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Diffusely distributed throughout the cytosol during pro-metaphase and metaphase. Detected at the dynamic cell poles during telophase. Detected at the cleavage furrow and contractile ring during cytokinesis. Transiently detected at the plasma membrane in late stages of cytokinesis. Detected at the midbody.
Tissue Specificity Ubiquitous. Highly expressed in all the regions of central nerve system except the spinal cord. Also expressed at high level in liver and testis. In fetus, it is weakly expressed in all organs except brain. {ECO:0000269|PubMed:14522954, ECO:0000269|PubMed:15580268}.
Top Pathways Vitamin B6 metabolism

pyridoxal phosphatase CRISPR/Cas9 KO Plasmid (h) - sc-406810 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

pyridoxal phosphatase HDR Plasmid (h) - sc-406810-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

pyridoxal phosphatase Double Nickase Plasmid (h) - sc-406810-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

pyridoxal phosphatase Double Nickase Plasmid (h2) - sc-406810-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

pyridoxal phosphatase CRISPR Activation Plasmid (h) - sc-406810-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

pyridoxal phosphatase CRISPR Activation Plasmid (h2) - sc-406810-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

pyridoxal phosphatase Lentiviral Activation Particles (h) - sc-406810-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

pyridoxal phosphatase Lentiviral Activation Particles (h2) - sc-406810-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

pyridoxal phosphatase siRNA (h) - sc-61425 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

pyridoxal phosphatase shRNA Plasmid (h) - sc-61425-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

pyridoxal phosphatase shRNA (h) Lentiviral Particles - sc-61425-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU222101 from Sigma-Aldrich

Category siRNA
Prices $140.00, $140.00
Sizes 20 µg, 50 µg

MISSION® Human Phosphatase - SIHP0388 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0390 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0389 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

CompoZr® Knockout ZFN Kit - CKOZFN16588 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16588 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07683 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07683

PDXP siRNA (Human) - CRJ1293 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PDXP RNAi - H00057026-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

pyridoxal phosphatase CRISPR/Cas9 KO Plasmid (h2) - sc-406810-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

pyridoxal phosphatase HDR Plasmid (h2) - sc-406810-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human PDXP (NM_020315.4) - SHH373152 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human PDXP(NM_020315.4) - SHR103398 from Creative biogene

Category siRNA
Species Reactivities Human

Human PDXP siRNA - orb271794 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human
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