CCL19

Gene Symbol CCL19
Entrez Gene 6363
Alt Symbol CKb11, ELC, MIP-3b, MIP3B, SCYA19
Species Human
Gene Type protein-coding
Description chemokine (C-C motif) ligand 19
Other Description C-C motif chemokine 19|CC chemokine ligand 19|CK beta-11|EBI1 ligand chemokine|EBI1-ligand chemokine|MIP-3-beta|beta chemokine exodus-3|beta-chemokine exodus-3|epstein-Barr virus-induced molecule 1 ligand chemokine|exodus-3|macrophage inflammatory protein 3 beta|macrophage inflammatory protein 3-beta|small inducible cytokine subfamily A (Cys-Cys), member 19|small-inducible cytokine A19
Swissprots O00697 O00736 Q99731
Accessions ABK41949 CAA11307 EAW58416 Q99731 AB000887 BAA20383 AK311945 BAG34886 AX772806 CAE06252 BC027968 AAH27968 CR456868 CAG33149 DQ895236 ABM86162 EU176240 ABW03691 U77180 AAC50944 U88321 AAC23905 NM_006274 NP_006265
Function May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. {ECO:0000269|PubMed:9498785}.
Subcellular Location Secreted.
Tissue Specificity Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach.
Top Pathways Cytokine-cytokine receptor interaction, Chemokine signaling pathway

MIP-3β (K-19) - sc-9778 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

MIP-3β (N-18) - sc-9777 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

MIP-3β (YNR-HMIP3) - sc-73329 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

MIP-3β (ZZ22) - sc-74233 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
MIP-3β (ZZ22): sc-74233. Western blot analysis of human recombinant MIP-3β.

MIP-3β (4i164) - sc-71584 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

MIP-3β (500-M29) - sc-65367 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
MIP-3β (500-M29): sc-65367. Western blot analysis of human recombinant MIP-3β.

Anti-Macrophage Inflammatory Protein 3 beta antibody - ab10389 from Abcam

Prices $379.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Immunohistochemistry analysis of human skin tissue. Tissue was fixed overnight in PBS-buffered 10% paraformaldehyde at 4°C, embedded in optimal cutting temperature compound, and frozen at −80°C. Cryosections were treated for antigen retrieval and blocking, then stained by incubation overnight at 4°C with primary antibodies in blocking solution: monoclonal mouse anti-human CCR7 (1:50) and ab10389 - polyclonal goat anti-human macrophage inflammatory protein 3 beta (1:50). Slides were incubated with fluorescent secondary goat anti-mouse Alexa488 and rabbit anti-goat Alexa647, in blocking solution (1:600) for 1 hour at room temperature. Nuclei were stained with Hoechst 33258.Four weeks of anti-TNF therapy induce lymphoid aggregate dissolution and reduction of CCR7 and CCL19 in the subpapillary dermis. Punch skin biopsy specimens were taken from the same lesional area at baseline and after 4 weeks of anti-TNF treatment (etanercept) from individual responder patients. Magnification: X40. Whi

Anti-Macrophage Inflammatory Protein 3 beta antibody - ab9831 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Macrophage Inflammatory Protein 3 beta antibody - ab9351 from Abcam

Prices $370.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal

Anti-Macrophage Inflammatory Protein 3 beta antibody [EPR7043(2)] - ab192871 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7043(2)
Anti-Macrophage Inflammatory Protein 3 beta antibody [EPR7043(2)] (ab192871) at 1/2000 dilution + Macrophage Inflammatory Protein 3 beta recombinant protein at 10 µgSecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-Macrophage Inflammatory Protein 3 beta antibody [EPR7044(2)] - ab192877 from Abcam

Prices $347.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7044(2)
Flow cytometric analysis of 2% paraformaldehyde-fixed A549 cells labeling Macrophage Inflammatory Protein 3 beta with ab192877 at 1/170 dilution (red) compared with a rabbit monoclonal IgG isotype control (black) and an unlabelled control (cells without incubation with primary antibody and secondary antibody; blue). Goat anti rabbit IgG (FITC) at 1/150 dilution was used as the secondary antibody.

Anti-Macrophage Inflammatory Protein 3 beta antibody [MM0143-11B4] - ab89339 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0143-11B4

Anti-CCL19 / MIP3-Beta Antibody (Biotin) - LS-C104502 from LifeSpan Bioscience

Prices $285.00, $325.00
Sizes 25 µg, 50 µg
Host Rabbit
Clonality Polyclonal

Anti-CCL19 / MIP3-Beta Antibody - LS-C190396 from LifeSpan Bioscience

Prices $590.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-CCL19 / MIP3-Beta Antibody (clone 3E9) - LS-C198168 from LifeSpan Bioscience

Prices $355.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 3E9

Anti-CCL19 / MIP3-Beta Antibody (clone YNR-HMIP3b) - LS-C204680 from LifeSpan Bioscience

Prices $265.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone YNR-HMIP3b

Anti-CCL19 / MIP3-Beta Antibody (N-Terminus, AP) - LS-C279037 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCL19 / MIP3-Beta Antibody (N-Terminus, APC) - LS-C279042 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCL19 / MIP3-Beta Antibody (N-Terminus, FITC) - LS-C279041 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCL19 / MIP3-Beta Antibody (N-Terminus, PE) - LS-C279043 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCL19 / MIP3-Beta Antibody (N-Terminus, Azide-free, HRP) - LS-C279044 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCL19 / MIP3-Beta Antibody (C-Terminus, AP) - LS-C279045 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCL19 / MIP3-Beta Antibody (C-Terminus, FITC) - LS-C279047 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCL19 / MIP3-Beta Antibody (C-Terminus, APC) - LS-C279046 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CCL19 / MIP3-Beta Antibody (C-Terminus, PE) - LS-C279049 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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