| Gene Symbol |
CCL19
|
| Entrez Gene |
6363
|
| Alt Symbol |
CKb11, ELC, MIP-3b, MIP3B, SCYA19
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chemokine (C-C motif) ligand 19
|
| Other Description |
C-C motif chemokine 19|CC chemokine ligand 19|CK beta-11|EBI1 ligand chemokine|EBI1-ligand chemokine|MIP-3-beta|beta chemokine exodus-3|beta-chemokine exodus-3|epstein-Barr virus-induced molecule 1 ligand chemokine|exodus-3|macrophage inflammatory protein 3 beta|macrophage inflammatory protein 3-beta|small inducible cytokine subfamily A (Cys-Cys), member 19|small-inducible cytokine A19
|
| Swissprots |
O00697 O00736 Q99731
|
| Accessions |
ABK41949 CAA11307 EAW58416 Q99731 AB000887 BAA20383 AK311945 BAG34886 AX772806 CAE06252 BC027968 AAH27968 CR456868 CAG33149 DQ895236 ABM86162 EU176240 ABW03691 U77180 AAC50944 U88321 AAC23905 NM_006274 NP_006265
|
| Function |
May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. {ECO:0000269|PubMed:9498785}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Chemokine signaling pathway
|
![Western Blot: Macrophage Inflammatory Protein 3 beta Overexpression Lysate (Adult Normal) [NBL1-08848] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Macrophage Inflammatory Protein 3 beta.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1124_Macrophage%2520Inflammatory%2520Protein%25203%2520beta%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08848-img0002.jpg)