| Gene Symbol | CCL19 |
|---|---|
| Entrez Gene | 6363 |
| Alt Symbol | CKb11, ELC, MIP-3b, MIP3B, SCYA19 |
| Species | Human |
| Gene Type | protein-coding |
| Description | chemokine (C-C motif) ligand 19 |
| Other Description | C-C motif chemokine 19|CC chemokine ligand 19|CK beta-11|EBI1 ligand chemokine|EBI1-ligand chemokine|MIP-3-beta|beta chemokine exodus-3|beta-chemokine exodus-3|epstein-Barr virus-induced molecule 1 ligand chemokine|exodus-3|macrophage inflammatory protein 3 beta|macrophage inflammatory protein 3-beta|small inducible cytokine subfamily A (Cys-Cys), member 19|small-inducible cytokine A19 |
| Swissprots | O00697 O00736 Q99731 |
| Accessions | ABK41949 CAA11307 EAW58416 Q99731 AB000887 BAA20383 AK311945 BAG34886 AX772806 CAE06252 BC027968 AAH27968 CR456868 CAG33149 DQ895236 ABM86162 EU176240 ABW03691 U77180 AAC50944 U88321 AAC23905 NM_006274 NP_006265 |
| Function | May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. {ECO:0000269|PubMed:9498785}. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach. |
| Top Pathways | Cytokine-cytokine receptor interaction, Chemokine signaling pathway |