CDH5

Gene Symbol CDH5
Entrez Gene 1003
Alt Symbol 7B4, CD144
Species Human
Gene Type protein-coding
Description cadherin 5, type 2 (vascular endothelium)
Other Description 7B4 antigen|VE-cadherin|cadherin 5, type 2, VE-cadherin (vascular epithelium)|cadherin-5|cd144 antigen|endothelial-specific cadherin|vascular endothelial cadherin
Swissprots Q4VAI6 Q4VAI5 P33151
Accessions EAW83009 P33151 AB035304 BAA87418 AB209908 BAD93145 AK300299 BAG62052 AK300322 BAG62074 AK300461 BAG62180 BC096363 AAH96363 BC096364 AAH96364 BC096365 AAH96365 BC117520 AAI17521 DC381809 U84722 AAB41796 X59796 CAA42468 X79981 CAA56306 XM_011522801 XP_011521103 NM_001795 NP_001786 NM_001114117
Function Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. {ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:21269602}.
Subcellular Location Cell junction {ECO:0000269|PubMed:20332120}. Cell membrane {ECO:0000305|PubMed:20332120}; Single-pass type I membrane protein {ECO:0000305|PubMed:20332120}. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions.
Tissue Specificity Endothelial tissues and brain.
Top Pathways Leukocyte transendothelial migration, Cell adhesion molecules (CAMs)

VE-Cadherin (D87F2) XP ® Rabbit mAb - 2500 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D87F2
Western blot analysis of extracts from HUVEC and BAEC cells using VE-Cadherin (D87F2) XP ® Rabbit mAb.

VE-Cadherin Antibody - 2158 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell types, using VE-Cadherin Antibody.

VE-cadherin (C-19) - sc-6458 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
VE-cadherin (C-19): sc-6458. Western blot analysis of VE-cadherin expression in rat placenta extract.

VE-cadherin (F-8) - sc-9989 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
VE-cadherin (F-8): sc-9989. Western blot analysis of VE-cadherin expression in HUV-EC-C whole cell lysate.

VE-cadherin (H-72) - sc-28644 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
VE-cadherin (H-72): sc-28644. Western blot analysis of VE-cadherin expression in human lung (A) and mouse placenta (B) tissue extracts.

VE-cadherin (BV9) - sc-52751 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
VE-cadherin (BV9): sc-sc-52751. Western blot analysis of VE-cadherin expression in human umbilical cord tissue extract.

VE-cadherin (N-14) - sc-31017 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-VE Cadherin (phospho Y685) antibody - ab119785 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-VE Cadherin (phospho Y685) antibody (ab119785) at 1/1000 dilutionLane 1 : Human umbilical vein endothelial cells stimulated with pervanadate (1 mM) for 30 min.Lane 2 : Human umbilical vein endothelial cells stimulated with pervanadate (1 mM) for 30 min then treated with alkaline phosphatase

Anti-VE Cadherin antibody - ab128597 from Abcam

Host Rabbit
Clonality Polyclonal
ab128597, at 1/100 dilution, staining VE Cadherin in Formalin-fixed, Paraffin-embedded Human fetal brain tissue by Immunohistochemistry.

Anti-VE Cadherin antibody - ab115828 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-VE Cadherin antibody (ab115828) at 1 µg/ml + Human fetal heart lysate at 10 µg

Anti-VE Cadherin antibody [16B1], prediluted (Allophycocyanin) - ab155350 from Abcam

Prices $188.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone 16B1
Staining of Human Umbilical Vein Endothelial Cells (HUVEC) with Mouse IgG1 kappa Isotype Control Allophycocyanin (open histogram) or ab155350 (filled histogram). Total viable cells were used for analysis

Anti-VE Cadherin antibody [3D5C7] - ab166715 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3D5C7
Anti-VE Cadherin antibody [3D5C7] (ab166715) at 1/500 dilution + Recombinant Human VE Cadherin protein - The recombinant protein is a fragment: AA: 29-223 containing a His-tag.

Anti-VE Cadherin antibody [BV9] - ab7047 from Abcam

Host Mouse
Clonality Monoclonal
Clone BV9
A confocal microscopy image of Endothelial cells from the breast expressing VE-cadherin. This image was kindly submitted as part of the review by Valgardur Sigurdsson.

Anti-VE Cadherin antibody (FITC) - ab33321 from Abcam

Prices $370.00
Sizes 50 tests
Host Rabbit
Clonality Polyclonal

Anti-VE Cadherin antibody - Intercellular Junction Marker - ab33168 from Abcam

Prices $403.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of VE-Cadherin staining on HUVEC cells using ab33168. The cells were incubated with the primary antibody (ab33168) and the secondary was FITC conjugated anti-rabbit used at 1:400. The cells were incubated with only the secondary antibody as a negative control.

Anti-CD144 / CDH5 / VE Cadherin Antibody (aa1-258) IHC-plus™ - LS-B2138 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-VE Cadherin antibody IHC of mouse liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2138 concentration 5 ug/ml.

Anti-CD144 / CDH5 / VE Cadherin Antibody (aa766-784) - LS-C313199 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
CD144 / CDH5 / VE Cadherin antibody. IHC(P): Rat Brain Tissue.

Anti-CD144 / CDH5 / VE Cadherin Antibody (C-Terminus) - LS-C4280 from LifeSpan Bioscience

Prices $445.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-CD144 / CDH5 / VE Cadherin Antibody (aa1-258, FITC) - LS-C40121 from LifeSpan Bioscience

Prices $485.00
Sizes 100 tst
Host Rabbit
Clonality Polyclonal

Anti-CD144 / CDH5 / VE Cadherin Antibody (FITC) - LS-C122779 from LifeSpan Bioscience

Prices $740.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-CD144 / CDH5 / VE Cadherin Antibody - LS-C122780 from LifeSpan Bioscience

Prices $620.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-CD144 / CDH5 / VE Cadherin Antibody (Extracellular Domain, APC) - LS-C132861 from LifeSpan Bioscience

Prices $590.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal

Anti-CD144 / CDH5 / VE Cadherin Antibody (clone BV9, FITC) - LS-C139965 from LifeSpan Bioscience

Prices $665.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone BV9

Anti-CD144 / CDH5 / VE Cadherin Antibody (clone 16B1, Biotin) - LS-C107330 from LifeSpan Bioscience

Prices $235.00, $325.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 16B1
Staining of Human Umbilical Vein Endothelial Cells (HUVEC) with 0.25 ug of Biotin Mouse IgG1, K isotype control (open histogram) or 0.125 ug of Biotin 16B1 (colored histogram) followed by Streptavidin-PE. Total viable cells were used for analysis.

Anti-CD144 / CDH5 / VE Cadherin Antibody (clone 16B1, APC) - LS-C107025 from LifeSpan Bioscience

Prices $205.00, $355.00
Sizes 25 tst, 100 tst
Host Mouse
Clonality Monoclonal
Clone 16B1
Staining of Human Umbilical Vein Endothelial Cells (HUVEC) with APC Mouse IgG1, K isotype control (open histogram) or APC anti-human CD144 (16B1) (colored histogram). Total viable cells were used for analysis.
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