CDH5

Gene Symbol	CDH5
Entrez Gene	1003
Alt Symbol	7B4, CD144
Species	Human
Gene Type	protein-coding
Description	cadherin 5, type 2 (vascular endothelium)
Other Description	7B4 antigen|VE-cadherin|cadherin 5, type 2, VE-cadherin (vascular epithelium)|cadherin-5|cd144 antigen|endothelial-specific cadherin|vascular endothelial cadherin
Swissprots	Q4VAI6 Q4VAI5 P33151
Accessions	EAW83009 P33151 AB035304 BAA87418 AB209908 BAD93145 AK300299 BAG62052 AK300322 BAG62074 AK300461 BAG62180 BC096363 AAH96363 BC096364 AAH96364 BC096365 AAH96365 BC117520 AAI17521 DC381809 U84722 AAB41796 X59796 CAA42468 X79981 CAA56306 XM_011522801 XP_011521103 NM_001795 NP_001786 NM_001114117
Function	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. {ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:21269602}.
Subcellular Location	Cell junction {ECO:0000269|PubMed:20332120}. Cell membrane {ECO:0000305|PubMed:20332120}; Single-pass type I membrane protein {ECO:0000305|PubMed:20332120}. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions.
Tissue Specificity	Endothelial tissues and brain.
Top Pathways	Leukocyte transendothelial migration, Cell adhesion molecules (CAMs)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human CD144 / CDH5 / VE Cadherin ELISA Kit (Cell-Based ELISA) - LS-F2383 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 312-20000 pg/ml

Mouse CD144 / CDH5 / VE Cadherin ELISA Kit (Sandwich ELISA) - LS-F2974 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 312 pg/ml Range 312-20000 pg/ml

Human CD144 / CDH5 / VE Cadherin ELISA Kit (Sandwich ELISA) - LS-F4576 from LifeSpan Bioscience Category ELISA Kit Prices $490.00 Sizes 1 plate Sensitivity 0.69 ng/ml Range 312-20000 pg/ml

Mouse CD144 / CDH5 / VE Cadherin ELISA Kit (Sandwich ELISA) - LS-F7270 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 312-20000 pg/ml

Rat CD144 / CDH5 / VE Cadherin ELISA Kit (Sandwich ELISA) - LS-F9170 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.117 ng/ml Range 312-20000 pg/ml

Human CD144 / CDH5 / VE Cadherin ELISA Kit (Sandwich ELISA) - LS-F10983 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 0.156 Range 312-20000 pg/ml

Human VE-Cadherin Quantikine ELISA Kit - DCADV0 from R&D Systems Category ELISA Kit Prices $509.00 Sizes 1 kit Sensitivity 0.236 ng/mL Range 1.6 - 100 ng/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma)

Human Total VE-Cadherin DuoSet IC ELISA, 2 Plate - DYC938-2 from R&D Systems Category ELISA Kit Prices $329.00 Sizes 1 kit (for 2 Plates) Range 312.00 - 20,000 pg/mL

Quantikine Immunoassay Control Set 672 for Human VE-Cadherin - QC184 from R&D Systems Category ELISA Kit Prices $125.00 Sizes 1 each

Human VE-Cadherin DuoSet ELISA - DY938-05 from R&D Systems Category ELISA Kit Prices $299.00 Sizes 1 kit (for 5 Plates) Range 0.312 - 20 ng/mL

Human CD144 ELISA Kit - abx055317 from Abbexa Category ELISA Kit

Cadherin 5 (CDH5), Human, ELISA Kit - SEB366Hu from ARP American Research Products Category ELISA Kit Prices $488.00 Sizes 96 t Sensitivity 0.52ng/mL Range 1.56-100ng/mL

Cadherin-5, CDH5, Human, ELISA Kit - E1366h from ARP American Research Products Category ELISA Kit Prices $476.00 Sizes 96 t Range 0.156-10 ng/mL

Vascular Endothelial-Cadherin Complex, VE-cad, Human, ELISA Kit - CSB-E09372h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Vascular Endothelial Cadherin, VE-Cadherin, Human, ELISA Kit - E-EL-H2157 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Vascular Endothelial Cadherin, VE-Cadherin, Mouse, ELISA Kit - E-EL-M0210 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Vascular Endothelial Cadherin, VE-Cadherin, Rat, ELISA Kit - E-EL-R0130 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Vascular Endothelial Cadherin, VE-Cadherin, Rabbit, ELISA Kit - E-EL-RB0474 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Vascular Endothelial Cadherin, VE-Cadherin, Chicken, ELISA Kit - E-EL-Ch1597 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Vascular Endothelial Cadherin, VE-Cadherin, Porcine, ELISA Kit - E-EL-P1492 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 18.75 Range 31.25-2000ng/mL

Vascular Endothelial Cadherin, VE-Cadherin, Sheep, ELISA Kit - E-EL-S0885 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t Sensitivity 0.375 Range 0.625-40ng/mL

Vascular Endothelial Cadherin, VE-Cadherin, Guinea Pig, ELISA Kit - E-EL-GP0668 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Vascular Endothelial Cadherin, VE-Cadherin, Monkey, ELISA Kit - E-EL-MK0077 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.113 Range 0.188-12U/mL

Human CDH5 ELISA Kit - HC0507 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine CDH5 ELISA Kit - AC0507 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

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