CDH5

Gene Symbol	CDH5
Entrez Gene	1003
Alt Symbol	7B4, CD144
Species	Human
Gene Type	protein-coding
Description	cadherin 5, type 2 (vascular endothelium)
Other Description	7B4 antigen|VE-cadherin|cadherin 5, type 2, VE-cadherin (vascular epithelium)|cadherin-5|cd144 antigen|endothelial-specific cadherin|vascular endothelial cadherin
Swissprots	Q4VAI6 Q4VAI5 P33151
Accessions	EAW83009 P33151 AB035304 BAA87418 AB209908 BAD93145 AK300299 BAG62052 AK300322 BAG62074 AK300461 BAG62180 BC096363 AAH96363 BC096364 AAH96364 BC096365 AAH96365 BC117520 AAI17521 DC381809 U84722 AAB41796 X59796 CAA42468 X79981 CAA56306 XM_011522801 XP_011521103 NM_001795 NP_001786 NM_001114117
Function	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. {ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:21269602}.
Subcellular Location	Cell junction {ECO:0000269|PubMed:20332120}. Cell membrane {ECO:0000305|PubMed:20332120}; Single-pass type I membrane protein {ECO:0000305|PubMed:20332120}. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions.
Tissue Specificity	Endothelial tissues and brain.
Top Pathways	Leukocyte transendothelial migration, Cell adhesion molecules (CAMs)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human VE Cadherin protein fragment - ab112269 from Abcam Category Protein Source Wheat germ Species Human

CD144 / CDH5 / VE Cadherin Antibody Blocking Peptide - LS-E22008 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD144 / CDH5 / VE Cadherin Blocking Peptide - LS-E7041 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

VE-Cadherin Partial Recombinant Protein - H00001003-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

VE-Cadherin Peptide - P1210 from Novus Biologicals Category Peptide Species Human

VE-Cadherin-Antibody-CDH5-N-term-Blocking-peptide - BP2724a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human VE-Cadherin Fc Chimera, CF - 938-VC-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Mouse VE-Cadherin Fc Chimera, CF - 1002-VC-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Human VE-Cadherin, CF - 8440-VC-025 from R&D Systems Category Protein Source Human embryonic kidney cell, HEK293-derived, Asp48-Gln599, with a C-terminal 6-His tag

Human Cadherin 5 Fc His tag protein - orb83935 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

CDH5 Blocking Peptide - 33R-8584 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human Cadherin 5 Protein - abx065628 from Abbexa Category Protein Source E.coli Species Human

CD144 / Cadherin-5 - H00001003-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD144 / Cadherin-5 - H00001003-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human Cadherin 5, Type 2 (Vascular Endothelium), Fc-His - CDH5-1696H from Creative Biomart Category Protein Source NSO Cells.

Recombinant Human CDH5, Fc-His tagged - CDH5-3245H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human CDH5 - CDH5-31200TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human CDH5, His-tagged - CDH5-501H from Creative Biomart Category Protein Source HEK293 cells Species Human

Recombinant Cadherin 5 (CDH5) - RPB366Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Cadherin 5 (CDH5) - RPB366Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Cadherin 5 (CDH5) - RPB366Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Cadherin 5 (CDH5) - RPB366Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Human VE-Cadherin / CD144 / CDH5 Protein (His & Fc Tag) - 10433-H03H-50 from Sino Biological Category Protein Prices $178.00, $298.00 Sizes 50 µg, 100 µg Source Human Cells Species Human

p-VE-Cadherin (Y731) Peptide - BS4242 P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Cadherin 5 (CDH5) - RPB366Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Search more