HMGCR

Gene Symbol	HMGCR
Entrez Gene	3156
Alt Symbol	LDLCQ3
Species	Human
Gene Type	protein-coding
Description	3-hydroxy-3-methylglutaryl-CoA reductase
Other Description	3-hydroxy-3-methylglutaryl CoA reductase (NADPH)\|3-hydroxy-3-methylglutaryl-Coenzyme A reductase\|HMG-CoA reductase\|hydroxymethylglutaryl-CoA reductase
Swissprots	B7Z3Y9 Q8N190 P04035
Accessions	AAG21343 AAP72015 CAZ64465 EAW95754 EAW95755 EAW95756 P04035 AA648735 AK292892 BAF85581 AK296499 BAH12375 AK299655 BAG61573 AK312437 BAG35346 AY429541 AY429542 AY429543 BC024180 BC033692 AAH33692 CN278665 DQ890855 ABM81781 DQ894009 ABM84935 M11058 AAA52679 M62627 M62633 XM_011543357 XP_011541659 XM_011543358 XP_011541660 XM_011543359 XP_011541661 NM_000859 NP_000850 NM_001130996 NP_001124468
Function	Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
Subcellular Location	Endoplasmic reticulum membrane; Multi-pass membrane protein.
Top Pathways	Terpenoid backbone biosynthesis, Bile secretion, AMPK signaling pathway

HMGCR (C-1) - sc-271595 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

HMGCR (C-1): sc-271595. Western blot analysis of HMGCR expression in non-transfected: sc-117752 (A) and mouse HMGCR transfected: sc-120842 (B) 293T whole cell lysates.

HMGCR (C-18) - sc-27578 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

HMGCR (C-18): sc-27578. Western blot analysis of HMGCR membrane-bound glycoprotein expression and HMGCR C-terminal cleavage product expression in Hep G2 (A) and TT (B) whole cell lysates.

HMGCR (H-300) - sc-33827 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

HMGCR (H-300): sc-33827. Western blot analysis of HMGCR expression in non-transfected: sc-117752 (A) and mouse HMGCR transfected: sc-120842 (B) 293T whole cell lysates.

HMGCR (K-15) - sc-27580 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-HMGCR antibody - ab99383 from Abcam

Prices	$376.00
Sizes	125 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-HMGCR antibody (ab99383) at 1/1000 dilutionLane 1 : UT2 cell lysateLane 2 : UT2 FL-HMGCR cell lysateLysates/proteins at 60 µg per lane.

Anti-HMGCR antibody [EPR1685(N)] - ab174830 from Abcam

Prices	$385.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR1685(N)

All lanes : Anti-HMGCR antibody [EPR1685(N)] (ab174830) at 1/300 dilution (unpurified)Lane 1 : Jurkat cell lysateLane 2 : TT cell lysateLysates/proteins at 10 µg per lane.SecondaryPeroxidase-conjugated goat anti-rabbit IgG (H+L) at 1/1000 dilution

Anti-HMG-CoA Reductase / HMGCR Antibody (aa295-308) - LS-C112813 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti-HMG-CoA Reductase / HMGCR Antibody - LS-C147064 from LifeSpan Bioscience

Prices	$445.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-HMG-CoA Reductase / HMGCR Antibody - LS-C310626 from LifeSpan Bioscience

Prices	$475.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-HMG-CoA Reductase / HMGCR Antibody - LS-C285529 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-HMG-CoA Reductase / HMGCR Antibody (aa571-855) - LS-C311702 from LifeSpan Bioscience

Prices	$250.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-HMG-CoA Reductase / HMGCR Antibody (Biotin) - LS-C317112 from LifeSpan Bioscience

Prices	$305.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-HMG-CoA Reductase / HMGCR Antibody (FITC) - LS-C318761 from LifeSpan Bioscience

Prices	$305.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-HMG-CoA Reductase / HMGCR Antibody - LS-C192794 from LifeSpan Bioscience

Prices	$385.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of extracts of various cell lines, using HMGCR antibody.

Anti-HMG-CoA Reductase / HMGCR Antibody (HRP) - LS-C318764 from LifeSpan Bioscience

Prices	$305.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-HMG-CoA Reductase / HMGCR Antibody (C-Terminus) - LS-C345433 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of HMDH Antibody with human Fetal Lung lysate.

Anti-HMG-CoA Reductase / HMGCR Antibody (C-Terminus) - LS-C345666 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of HMDH Antibody with human MCF7 Whole Cell lysate.

Anti-HMG-CoA Reductase / HMGCR Antibody - LS-C331599 from LifeSpan Bioscience

Prices	$255.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry of paraffin-embedded human kidney using IL23R antibody at dilution of 1:200 (x400 lens)

HMG-CoA Reductase/HMGCR Antibody - 46580002 from Novus Biologicals

Prices	$329.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

HMG-CoA Reductase/HMGCR Antibody - NBP1-91996 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry: HMGCR Antibody [NBP1-91996] - Staining of human colon shows strong cytoplasmic positivity in glandular cells.

HMG-CoA Reductase/HMGCR Antibody - NBP1-36961 from Novus Biologicals

Prices	$229.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

HMGCR Antibody - H00003156-D01 from Novus Biologicals

Prices	$399.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

HMGCR(Ser872) Polyclonal Antibody - bs-4063R from Bioss

Prices	$299.50
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Formalin-fixed and paraffin embedded rat liver tissue labeled with Anti-phospho-HMGCR(Ser872) Polyclonal Antibody, Unconjugated (bs-4063R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

HMGCR Polyclonal Antibody - bs-5068R from Bioss

Prices	$279.50
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Formalin-fixed and paraffin embedded rat brain labeled with Anti-HMGCR Polyclonal Antibody, Unconjugated (bs-5068R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Anti-HMGCR antibody produced in rabbit - SAB4200528 from Sigma-Aldrich

Prices	$337.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunofluorescence</B><BR/>Mevastatin-treated HepG2 cells were fixed and permeabilized with 4% paraformaldehyde followed by 0.5% Triton X-100. Fixed cells were stained with 1 μg/mL Rabbit Anti-HMGCR (<B>Cat. No. SAB4200528</B>). The antibody was developed using Goat Anti-Rabbit IgG, Cy3 conjugate. Cells were counterstained with DAPI (blue) to stain nuclei.

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