HMGCR

Gene Symbol HMGCR
Entrez Gene 3156
Alt Symbol LDLCQ3
Species Human
Gene Type protein-coding
Description 3-hydroxy-3-methylglutaryl-CoA reductase
Other Description 3-hydroxy-3-methylglutaryl CoA reductase (NADPH)|3-hydroxy-3-methylglutaryl-Coenzyme A reductase|HMG-CoA reductase|hydroxymethylglutaryl-CoA reductase
Swissprots B7Z3Y9 Q8N190 P04035
Accessions AAG21343 AAP72015 CAZ64465 EAW95754 EAW95755 EAW95756 P04035 AA648735 AK292892 BAF85581 AK296499 BAH12375 AK299655 BAG61573 AK312437 BAG35346 AY429541 AY429542 AY429543 BC024180 BC033692 AAH33692 CN278665 DQ890855 ABM81781 DQ894009 ABM84935 M11058 AAA52679 M62627 M62633 XM_011543357 XP_011541659 XM_011543358 XP_011541660 XM_011543359 XP_011541661 NM_000859 NP_000850 NM_001130996 NP_001124468
Function Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein.
Top Pathways Terpenoid backbone biosynthesis, Bile secretion, AMPK signaling pathway

HMGCR CRISPR/Cas9 KO Plasmid (h) - sc-400560 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HMGCR HDR Plasmid (h) - sc-400560-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HMGCR Double Nickase Plasmid (h) - sc-400560-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HMGCR Double Nickase Plasmid (h2) - sc-400560-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HMGCR CRISPR Activation Plasmid (h) - sc-400560-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HMGCR CRISPR Activation Plasmid (h2) - sc-400560-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HMGCR Lentiviral Activation Particles (h) - sc-400560-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HMGCR Lentiviral Activation Particles (h2) - sc-400560-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HMGCR siRNA (h) - sc-43838 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HMGCR shRNA Plasmid (h) - sc-43838-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HMGCR shRNA (h) Lentiviral Particles - sc-43838-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU079561 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10166 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10166 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10334 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr10334

HMGCR siRNA (Human) - CRH2153 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HMGCR - MBS8210434 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human HMGCR (NM_000859.2) - SHH313373 from Creative biogene

Category siRNA
Species Reactivities Human

Human HMGCR siRNA - orb262655 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HMGCR shRNA Plasmid (Human) - CHH2153 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

HMGCR miRNA 3'UTR clone - MiUTR3H-01092 from Creative biogene

Species Reactivities Human

HMGCR miRNA 3'UTR clone - MiUTR3H-01093 from Creative biogene

Species Reactivities Human
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