| Gene Symbol |
Cpb2
|
| Entrez Gene |
113936
|
| Alt Symbol |
-
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
carboxypeptidase B2 (plasma)
|
| Other Description |
CPR|CPU|TAFI|carboxypeptidase B2|carboxypeptidase R|carboxypeptidase U|thrombin-activable fibrinolysis inhibitor
|
| Swissprots |
Q3B7V3 Q5BKB8 Q9EQV9
|
| Accessions |
EDM02289 EDM02290 Q9EQV9 BC091133 AAH91133 BC107447 AAI07448 DY312674 FQ210930 FQ218610 FQ218635 FQ218700 FQ219505 FQ219645 NM_053617 NP_446069
|
| Function |
Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. {ECO:0000269|PubMed:11021404}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Plasma; synthesized in the liver.
|
| Top Pathways |
Complement and coagulation cascades, Protein digestion and absorption, Pancreatic secretion
|
