| Gene Symbol | Cpb2 |
|---|---|
| Entrez Gene | 113936 |
| Alt Symbol | - |
| Species | Rat |
| Gene Type | protein-coding |
| Description | carboxypeptidase B2 (plasma) |
| Other Description | CPR|CPU|TAFI|carboxypeptidase B2|carboxypeptidase R|carboxypeptidase U|thrombin-activable fibrinolysis inhibitor |
| Swissprots | Q3B7V3 Q5BKB8 Q9EQV9 |
| Accessions | EDM02289 EDM02290 Q9EQV9 BC091133 AAH91133 BC107447 AAI07448 DY312674 FQ210930 FQ218610 FQ218635 FQ218700 FQ219505 FQ219645 NM_053617 NP_446069 |
| Function | Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. {ECO:0000269|PubMed:11021404}. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Plasma; synthesized in the liver. |
| Top Pathways | Complement and coagulation cascades, Protein digestion and absorption, Pancreatic secretion |
CompoZr® Knockout ZFN Kit - CKOZFN52393 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND52393 from Sigma-Aldrich
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CPB2 siRNA (Rat) - CRR2777 from Cohesion Biosciences
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CPB2 - MBS8200345 from MyBioSource
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shRNA set against Rat CPB2 (NM_053617.2) - SHH268581 from Creative biogene
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shRNA set against Rat Cpb2(NM_053617.2) - SHG195593 from Creative biogene
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CPB2 shRNA Plasmid (Rat) - CHR2777 from Cohesion Biosciences
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CPB2 miRNA 3'UTR clone - MiUTR1R-01147 from Creative biogene
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