Gene Symbol | Cpb2 |
---|---|
Entrez Gene | 113936 |
Alt Symbol | - |
Species | Rat |
Gene Type | protein-coding |
Description | carboxypeptidase B2 (plasma) |
Other Description | CPR|CPU|TAFI|carboxypeptidase B2|carboxypeptidase R|carboxypeptidase U|thrombin-activable fibrinolysis inhibitor |
Swissprots | Q3B7V3 Q5BKB8 Q9EQV9 |
Accessions | EDM02289 EDM02290 Q9EQV9 BC091133 AAH91133 BC107447 AAI07448 DY312674 FQ210930 FQ218610 FQ218635 FQ218700 FQ219505 FQ219645 NM_053617 NP_446069 |
Function | Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. {ECO:0000269|PubMed:11021404}. |
Subcellular Location | Secreted. |
Tissue Specificity | Plasma; synthesized in the liver. |
Top Pathways | Complement and coagulation cascades, Protein digestion and absorption, Pancreatic secretion |