Mapk3
| Gene Symbol | Mapk3 |
|---|---|
| Entrez Gene | 26417 |
| Alt Symbol | Erk-1, Erk1, Ert2, Esrk1, Mnk1, Mtap2k, Prkm3, p44, p44erk1, p44mapk |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | mitogen-activated protein kinase 3 |
| Other Description | MAP kinase 3|extracellular signal-regulated kinase 1|insulin-stimulated MAP2 kinase|microtubule-associated protein 2 kinase|p44 MAP kinase|pp42/MAP kinase |
| Swissprots | Q63844 Q8K0X5 Q61531 Q91YW5 |
| Accessions | Q63844 AK155287 BAE33167 BC013754 AAH13754 BC029712 AAH29712 BQ929318 S58470 AAB19973 X64605 CAA45889 Z14249 NM_011952 NP_036082 |
| Function | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organel |
| Subcellular Location | Cytoplasm. Nucleus. Note=Autophosphorylation at Thr-207 promotes nuclear localization (By similarity). PEA15- binding redirects the biological outcome of MAPK3 kinase-signaling by sequestering MAPK3 into the cytoplasm. {ECO:0000250}. |
| Top Pathways | TGF-beta signaling pathway, Adherens junction, Axon guidance, VEGF signaling pathway, Focal adhesion |
ERK1 Polyclonal Antibody - bs-1020R from Bioss
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ERK1 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-1020R-A350 from Bioss
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ERK1 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-1020R-A488 from Bioss
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ERK1 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-1020R-A555 from Bioss
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ERK1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-1020R-A647 from Bioss
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ERK1 Polyclonal Antibody, Cy3 Conjugated - bs-1020R-Cy3 from Bioss
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ERK1 Polyclonal Antibody, Cy5 Conjugated - bs-1020R-Cy5 from Bioss
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ERK1 Polyclonal Antibody, Cy5.5 Conjugated - bs-1020R-Cy5.5 from Bioss
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ERK1 Polyclonal Antibody, Cy7 Conjugated - bs-1020R-Cy7 from Bioss
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ERK1 Polyclonal Antibody, FITC Conjugated - bs-1020R-FITC from Bioss
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ERK1 Polyclonal Antibody, PE Conjugated - bs-1020R-PE from Bioss
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ERK1 Polyclonal Antibody, Biotin Conjugated - bs-1020R-Biotin from Bioss
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ERK1 Polyclonal Antibody, HRP Conjugated - bs-1020R-HRP from Bioss
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Mouse-Mapk3-Antibody-C-term - AP14266b from Abgent, a WuXi AppTec company
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Mouse-Mapk3-Antibody-C-term - AW5034 from Abgent, a WuXi AppTec company
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Mouse Mapk3 Antibody - C-terminal region (OAAB10565) - OAAB10565 from Aviva Systems Biology
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MAPK3 Antibody (OABF00385) - OABF00385 from Aviva Systems Biology
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MAPK3 antibody - 70R-31926 from Fitzgerald
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p44/42 MAP Kinase antibody (Thr202) - 70R-34116 from Fitzgerald
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ERK1/2 antibody - 70R-31177 from Fitzgerald
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p44/42 MAP Kinase antibody - 70R-34119 from Fitzgerald
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ERK1/2 antibody (Thr202/Tyr204) - 70R-37410 from Fitzgerald
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p44/42 MAP Kinase antibody - 70R-34117 from Fitzgerald
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p44 MAPK antibody - 70R-31657 from Fitzgerald
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p44/42 MAP Kinase antibody (Tyr204) - 70R-34118 from Fitzgerald
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