| Gene Symbol | Mapk3 |
|---|---|
| Entrez Gene | 26417 |
| Alt Symbol | Erk-1, Erk1, Ert2, Esrk1, Mnk1, Mtap2k, Prkm3, p44, p44erk1, p44mapk |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | mitogen-activated protein kinase 3 |
| Other Description | MAP kinase 3|extracellular signal-regulated kinase 1|insulin-stimulated MAP2 kinase|microtubule-associated protein 2 kinase|p44 MAP kinase|pp42/MAP kinase |
| Swissprots | Q63844 Q8K0X5 Q61531 Q91YW5 |
| Accessions | Q63844 AK155287 BAE33167 BC013754 AAH13754 BC029712 AAH29712 BQ929318 S58470 AAB19973 X64605 CAA45889 Z14249 NM_011952 NP_036082 |
| Function | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organel |
| Subcellular Location | Cytoplasm. Nucleus. Note=Autophosphorylation at Thr-207 promotes nuclear localization (By similarity). PEA15- binding redirects the biological outcome of MAPK3 kinase-signaling by sequestering MAPK3 into the cytoplasm. {ECO:0000250}. |
| Top Pathways | TGF-beta signaling pathway, Adherens junction, Axon guidance, VEGF signaling pathway, Focal adhesion |
Mouse-Mapk3-Antibody-C-term-Blocking-Peptide - BP14266b from Abgent, a WuXi AppTec company
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Recombinant Mouse Mitogen-activated protein kinase 3(Mapk3) - CSB-YP013456MO CSB-EP013456MO CSB-BP013456MO CSB-MP013456MO from Cusabio
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Recombinant Mouse MAPK3 Protein - MAPK3-9534M from Creative Biomart
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Mitogen-activated protein kinase 3 (Mapk3), Recombinant Protein - MBS1319724 from MyBioSource
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