Mapk3

Gene Symbol	Mapk3
Entrez Gene	26417
Alt Symbol	Erk-1, Erk1, Ert2, Esrk1, Mnk1, Mtap2k, Prkm3, p44, p44erk1, p44mapk
Species	Mouse
Gene Type	protein-coding
Description	mitogen-activated protein kinase 3
Other Description	MAP kinase 3|extracellular signal-regulated kinase 1|insulin-stimulated MAP2 kinase|microtubule-associated protein 2 kinase|p44 MAP kinase|pp42/MAP kinase
Swissprots	Q63844 Q8K0X5 Q61531 Q91YW5
Accessions	Q63844 AK155287 BAE33167 BC013754 AAH13754 BC029712 AAH29712 BQ929318 S58470 AAB19973 X64605 CAA45889 Z14249 NM_011952 NP_036082
Function	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organel
Subcellular Location	Cytoplasm. Nucleus. Note=Autophosphorylation at Thr-207 promotes nuclear localization (By similarity). PEA15- binding redirects the biological outcome of MAPK3 kinase-signaling by sequestering MAPK3 into the cytoplasm. {ECO:0000250}.
Top Pathways	TGF-beta signaling pathway, Adherens junction, Axon guidance, VEGF signaling pathway, Focal adhesion

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® p44 MAPK (Erk1) siRNA I (Mouse Specific) - 6352 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

ERK 1 CRISPR/Cas9 KO Plasmid (m) - sc-424052 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

ERK 1 HDR Plasmid (m) - sc-424052-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

ERK 1 Double Nickase Plasmid (m) - sc-424052-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

ERK 1 Double Nickase Plasmid (m2) - sc-424052-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

ERK 1 CRISPR Activation Plasmid (m) - sc-424052-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

ERK 1 CRISPR Activation Plasmid (m2) - sc-424052-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

ERK 1 Lentiviral Activation Particles (m) - sc-424052-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

ERK 1 Lentiviral Activation Particles (m2) - sc-424052-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

ERK 1 siRNA (m) - sc-29308 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

ERK 1 shRNA Plasmid (m) - sc-29308-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

ERK 1 shRNA (m) Lentiviral Particles - sc-29308-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

ERK 1 siRNA (m2) - sc-44206 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

ERK 1 shRNA Plasmid (m2) - sc-44206-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

ERK 1 shRNA (m2) Lentiviral Particles - sc-44206-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

MISSION® esiRNA - EMU064851 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN35261 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND35261 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MAPK3 siRNA (Mouse) - CRM4731 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

shRNA set against Mouse MAPK3 (NM_011952.2) - SHH338031 from Creative biogene Category siRNA Species Reactivities Mouse

shRNA set against Mouse Mapk3(NM_011952.2) - SHH175651 from Creative biogene Category siRNA Species Reactivities Mouse

Mouse MAPK3 siRNA - orb284207 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

MAPK3 shRNA Plasmid (Mouse) - CHM4731 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Mouse

MAPK3 miRNA 3'UTR clone - MiUTR1M-06939 from Creative biogene Species Reactivities Mouse

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