EPHB2

Gene Symbol	EPHB2
Entrez Gene	2048
Alt Symbol	CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5
Species	Human
Gene Type	protein-coding
Description	EPH receptor B2
Other Description	EPH-like kinase 5|developmentally-regulated Eph-related tyrosine kinase|elk-related tyrosine kinase|eph tyrosine kinase 3|ephrin type-B receptor 2|protein-tyrosine kinase HEK5|renal carcinoma antigen NY-REN-47|tyrosine-protein kinase TYRO5|tyrosine-protein kinase receptor EPH-3
Swissprots	Q5T0U7 O43477 Q5T0U8 Q5T0U6 P29323
Accessions	CAA41981 CAD83767 CAT16948 EAW95022 EAW95023 EAW95024 EAW95025 EAW95026 P29323 AB210018 BAE06100 AF025304 AAB94602 AK298898 BAG61009 AK299701 BAG61602 AL530874 BC007903 BC018763 BC041017 BC067861 AAH67861 BC146296 AAI46297 BQ641281 D14717 BAA03537 D31661 BAA06506 D37827 BAA07073 HM437237 ADN43068 L36643 AAA74244 L41939 AAA99310 XM_006710441 XP_006710504 XM_006710442 XP_006710505 XM_011540976 XP_011539278 NM_004442 NP_004433 NM_017449 NP_059145
Function	Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of developm
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}.
Tissue Specificity	Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EphB2 Antibody - 14389 from Cell Signaling Technology Prices $239.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

EphB2 (2D12C6) - sc-130068 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

EphB2 (A-15) - sc-27107 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

EphB2 (H-80) - sc-28980 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

EphB2 (C-20) - sc-1763 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

EphB2 (D-15) - sc-27108 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

EphB2 (48CT12.6.4) - sc-130752 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

EphB2 (SY4) - sc-100298 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-Eph receptor B2 antibody - ab5418 from Abcam Prices $390.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-Eph receptor B2 antibody - ab5425 from Abcam Prices $379.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-Eph receptor B2 antibody - ab54650 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-Eph receptor B2 antibody - ab70014 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-EPHB2 / EPH Receptor B2 Antibody (C-Terminus) - LS-C23126 from LifeSpan Bioscience Prices $485.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-EPHB2 / EPH Receptor B2 Antibody (aa226-325) - LS-C125534 from LifeSpan Bioscience Prices $425.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-EPHB2 / EPH Receptor B2 Antibody (aa27-551) - LS-C125535 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Rat Clonality Monoclonal

Anti-EPHB2 / EPH Receptor B2 Antibody (aa27-551) - LS-C125536 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Rat Clonality Monoclonal

Anti-EPHB2 / EPH Receptor B2 Antibody (aa27-551, clone 12K86, PE) - LS-C182843 from LifeSpan Bioscience Prices $575.00 Sizes 100 tst Host Rat Clonality Monoclonal Clone 12K86

Anti-EPHB2 / EPH Receptor B2 Antibody (aa27-551, clone 12K86, PerCP) - LS-C182842 from LifeSpan Bioscience Prices $605.00 Sizes 100 tst Host Rat Clonality Monoclonal Clone 12K86

Anti-EPHB2 / EPH Receptor B2 Antibody (aa882-893) - LS-C54793 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-EPHB2 / EPH Receptor B2 Antibody - LS-C184225 from LifeSpan Bioscience Prices $605.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-EPHB2 / EPH Receptor B2 Antibody (aa19-543, clone TS106) - LS-C191443 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone TS106

Anti-EPHB2 / EPH Receptor B2 Antibody (AP) - LS-C225395 from LifeSpan Bioscience Prices $515.00 Sizes 100 µl Host Mouse Clonality Monoclonal

Anti-EPHB2 / EPH Receptor B2 Antibody (clone 1F10) - LS-C197147 from LifeSpan Bioscience Prices $355.00 Sizes 200 µl Host Mouse Clonality Monoclonal Clone 1F10

Anti-EPHB2 / EPH Receptor B2 Antibody (aa27-548) - LS-C150108 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-EPHB2 / EPH Receptor B2 Antibody (Biotin) - LS-C225398 from LifeSpan Bioscience Prices $515.00 Sizes 100 µl Host Mouse Clonality Monoclonal

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