EPHB2

Gene Symbol	EPHB2
Entrez Gene	2048
Alt Symbol	CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5
Species	Human
Gene Type	protein-coding
Description	EPH receptor B2
Other Description	EPH-like kinase 5|developmentally-regulated Eph-related tyrosine kinase|elk-related tyrosine kinase|eph tyrosine kinase 3|ephrin type-B receptor 2|protein-tyrosine kinase HEK5|renal carcinoma antigen NY-REN-47|tyrosine-protein kinase TYRO5|tyrosine-protein kinase receptor EPH-3
Swissprots	Q5T0U7 O43477 Q5T0U8 Q5T0U6 P29323
Accessions	CAA41981 CAD83767 CAT16948 EAW95022 EAW95023 EAW95024 EAW95025 EAW95026 P29323 AB210018 BAE06100 AF025304 AAB94602 AK298898 BAG61009 AK299701 BAG61602 AL530874 BC007903 BC018763 BC041017 BC067861 AAH67861 BC146296 AAI46297 BQ641281 D14717 BAA03537 D31661 BAA06506 D37827 BAA07073 HM437237 ADN43068 L36643 AAA74244 L41939 AAA99310 XM_006710441 XP_006710504 XM_006710442 XP_006710505 XM_011540976 XP_011539278 NM_004442 NP_004433 NM_017449 NP_059145
Function	Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of developm
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}.
Tissue Specificity	Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human EphB2 gene - orb91477 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human-EPHB2-cDNA-Clone - DC08630 from Abgent, a WuXi AppTec company Prices $650.70 Sizes 10 µg Species Human Accession BC067861

EPHB2 - MBS1269717 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC067861

Human EPHB2 ORF Clone(NM_004442.6) - CDCR288017 from Creative Biomart Species Human Accession NM_004442.6

Human EPHB2 ORF Clone(NM_004442.6) - CDCR288018 from Creative Biomart Species Human Accession NM_004442.6

Human EphB2 ORF clone(NM_004442.6) - CDCL184074 from Creative Biomart Species Human Accession NM_004442.6

Human EphB2/Eph Receptor B2 Gene ORF cDNA clone in cloning vector - HG10762-M from Sino Biological Species Human

Human EphB2/Eph Receptor B2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10762-NF from Sino Biological Species Human

Human EphB2/Eph Receptor B2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10762-NM from Sino Biological Species Human

Human EphB2 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged - HG10762-M-F from Sino Biological Species Human Accession NM_004442.6

Human EphB2/Eph Receptor B2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10762-ACG from Sino Biological Species Human

Human EphB2/Eph Receptor B2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10762-CF from Sino Biological Species Human

Human EphB2/Eph Receptor B2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10762-CY from Sino Biological Species Human

Human EphB2/Eph Receptor B2 Gene ORF cDNA clone expression plasmid, N-His tag - HG10762-NH from Sino Biological Species Human

Human EphB2/Eph Receptor B2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10762-CM from Sino Biological Species Human

Human EphB2/Eph Receptor B2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10762-NY from Sino Biological Species Human

Human EphB2/Eph Receptor B2 Gene ORF cDNA clone expression plasmid, C-His tag - HG10762-CH from Sino Biological Species Human

Human EphB2/Eph Receptor B2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10762-ACR from Sino Biological Species Human

Human EphB2/Eph Receptor B2 Gene ORF cDNA clone expression plasmid - HG10762-UT from Sino Biological Species Human

Human EphB2 (NP_059145) VersaClone cDNA - RDC1279 from R&D Systems Prices $499.00 Sizes 10 µg Species Human

Human EphB2 ORF clone(NM_004442.6) - CDCL184074 from Creative biogene Species Human

Human EPHB2 ORF clone (NM_017449.3) - CDCR060808 from Creative biogene Species Human

Human EPHB2 ORF Clone (BC067861) - CDCS411785 from Creative biogene Species Human Accession P29323

Human ERK2/MAPK1/MAPK2 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG10030-ANG from Sino Biological Species Human

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