EPHB2

Gene Symbol	EPHB2
Entrez Gene	2048
Alt Symbol	CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5
Species	Human
Gene Type	protein-coding
Description	EPH receptor B2
Other Description	EPH-like kinase 5|developmentally-regulated Eph-related tyrosine kinase|elk-related tyrosine kinase|eph tyrosine kinase 3|ephrin type-B receptor 2|protein-tyrosine kinase HEK5|renal carcinoma antigen NY-REN-47|tyrosine-protein kinase TYRO5|tyrosine-protein kinase receptor EPH-3
Swissprots	Q5T0U7 O43477 Q5T0U8 Q5T0U6 P29323
Accessions	CAA41981 CAD83767 CAT16948 EAW95022 EAW95023 EAW95024 EAW95025 EAW95026 P29323 AB210018 BAE06100 AF025304 AAB94602 AK298898 BAG61009 AK299701 BAG61602 AL530874 BC007903 BC018763 BC041017 BC067861 AAH67861 BC146296 AAI46297 BQ641281 D14717 BAA03537 D31661 BAA06506 D37827 BAA07073 HM437237 ADN43068 L36643 AAA74244 L41939 AAA99310 XM_006710441 XP_006710504 XM_006710442 XP_006710505 XM_011540976 XP_011539278 NM_004442 NP_004433 NM_017449 NP_059145
Function	Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of developm
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}.
Tissue Specificity	Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active Eph receptor B2 protein fragment - ab60851 from Abcam Category Protein Prices $294.00 Sizes 10 µg Source Baculovirus infected sf9 cells

Active human Eph receptor B2 protein fragment - ab42607 from Abcam Category Protein Prices $321.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human Eph receptor B2 protein fragment - ab158375 from Abcam Category Protein Source Wheat germ Species Human

EPHB2 / EPH Receptor B2 Antibody Blocking Peptide - LS-E28656 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

EPHB2 / EPH Receptor B2 Antibody Blocking Peptide - LS-E28655 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

EPHB2 / EPH Receptor B2 Antibody Blocking Peptide - LS-E26179 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EPHB2 / EPH Receptor B2 Antibody Blocking Peptide - LS-E9114 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EPHB2 / EPH Receptor B2 Antibody Blocking Peptide - LS-E9115 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EphB2 Partial Recombinant Protein - H00002048-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

EphB2 Recombinant Protein - P3858 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Species Human

Recombinant Human EphB2 Protein - P4683 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Source Insect Species Human

EphB2 Peptide - P2634 from Novus Biologicals Category Peptide Species Human

EphB2-Antibody-C-term-Blocking-Peptide - BP7623b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CAPZB blocking peptide - GTX89785-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

EphB2 blocking peptide - GTX89205-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

Recombinant Human EphB2 Fc Chimera, CF - 5189-B2-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Human EphB2 protein - orb138787 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

Human EphB2 Fc His tag protein - orb82980 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

Human EphB2 protein (GST Tag) - orb138786 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Baculovirus-Insect Cells Species Human

Human EphB2 His tag protein - orb83280 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

ErbB4 protein - 30R-2884 from Fitzgerald Category Protein Prices $250.00 Sizes 5 µg Source Sf-9 insect cells Species Human

MAPK1 protein (His tag) - 80R-1232 from Fitzgerald Category Protein Prices $220.00 Sizes 100 µg Source E.coli

Eph Receptor B2 Peptide - AC21-1010-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

EPHB2 - H00002048-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

EPHB2 - H00002048-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

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