| Gene Symbol |
CREBBP
|
| Entrez Gene |
1387
|
| Alt Symbol |
CBP, KAT3A, RSTS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CREB binding protein
|
| Other Description |
CREB-binding protein
|
| Swissprots |
Q16376 D3DUC9 Q4LE28 Q92793 O00147
|
| Accessions |
AAC08447 AAC17736 ACF57233 ACF57234 ACF57235 ACF57236 ACF57237 ACF57238 ACF57239 ACF57240 ACF57241 ACF57242 ACF57243 ACF57244 ACF57245 ACF57246 ACF57247 ACF57248 ACF57249 ACF57250 ACF57251 ACF57252 ACF57253 ACF57254 ACF57255 ACF57256 ACF57257 ACF57258 ACF57259 ACF57260 ACF57261 ACF57262 ACF57263 ACF57264 ACF57265 ACF57266 ACF57267 ACF57268 ACF57269 ACF57270 ACF57271 ACF57272 ACF57273 ACF57274 ACF57275 ACF57276 CAL00150 CBX47651 CBX47652 EAW85334 EAW85335 EAW85336 EAW85337 Q92793 AB210043 BAE06125 AK124320 AK304771 BAG65526 BC036486 AAH36486 U47741 AAC51770 U85962 AAC51331 U89354 AAC51339 U89355 AAC51340 XM_005255124 XP_005255181 XM_005255125 XP_005255182 XM_006720848 XP_006720911 XM_011522380 XP_011520682 XM_011522381 XP_011520683 XM_011522382 XP_011520684 NM_001079846 NP_001073315 NM_004380 NP_004371
|
| Function |
Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2- ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. {ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:9707565}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus.
|
| Top Pathways |
Viral carcinogenesis, Glucagon signaling pathway, Epstein-Barr virus infection, MicroRNAs in cancer, cAMP signaling pathway
|