CREBBP

Gene Symbol CREBBP
Entrez Gene 1387
Alt Symbol CBP, KAT3A, RSTS
Species Human
Gene Type protein-coding
Description CREB binding protein
Other Description CREB-binding protein
Swissprots Q16376 D3DUC9 Q4LE28 Q92793 O00147
Accessions AAC08447 AAC17736 ACF57233 ACF57234 ACF57235 ACF57236 ACF57237 ACF57238 ACF57239 ACF57240 ACF57241 ACF57242 ACF57243 ACF57244 ACF57245 ACF57246 ACF57247 ACF57248 ACF57249 ACF57250 ACF57251 ACF57252 ACF57253 ACF57254 ACF57255 ACF57256 ACF57257 ACF57258 ACF57259 ACF57260 ACF57261 ACF57262 ACF57263 ACF57264 ACF57265 ACF57266 ACF57267 ACF57268 ACF57269 ACF57270 ACF57271 ACF57272 ACF57273 ACF57274 ACF57275 ACF57276 CAL00150 CBX47651 CBX47652 EAW85334 EAW85335 EAW85336 EAW85337 Q92793 AB210043 BAE06125 AK124320 AK304771 BAG65526 BC036486 AAH36486 U47741 AAC51770 U85962 AAC51331 U89354 AAC51339 U89355 AAC51340 XM_005255124 XP_005255181 XM_005255125 XP_005255182 XM_006720848 XP_006720911 XM_011522380 XP_011520682 XM_011522381 XP_011520683 XM_011522382 XP_011520684 NM_001079846 NP_001073315 NM_004380 NP_004371
Function Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2- ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. {ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:9707565}.
Subcellular Location Cytoplasm. Nucleus. Note=Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus.
Top Pathways Viral carcinogenesis, Glucagon signaling pathway, Epstein-Barr virus infection, MicroRNAs in cancer, cAMP signaling pathway

Acetyl-CBP (Lys1535)/p300 (Lys1499) Antibody - 4771 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from A431, NIH/3T3, COS and PC12 cells, using Acetyl-CBP (Lys1535)/p300 (Lys1499) Antibody.

CBP (D9B6) Rabbit mAb - 7425 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D9B6
Western blot analysis of extracts from various cell lines using CBP (D9B6) Rabbit mAb.

CBP (D6C5) Rabbit mAb - 7389 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D6C5
Western blot analysis of extracts from various cell lines using CBP (D6C5) Rabbit mAb.

CBP Antibody - 4772 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa, A431, PL45, HT29 and A549 cells using CBP Antibody.

CBP (F-12) - sc-365915 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CBP (F-12): sc-365915. Western blot analysis of CBP expression in Jurkat whole cell lysate.

CBP (C-20) - sc-583 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CBP (C-20): sc-583. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human pancreas tissue showing nuclear staining.

CBP (F-4) - sc-271974 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CBP (F-4): sc-271974. Western blot analysis of CBP expression in HeLa (A) and Jurkat (B) nuclear extracts.

CBP (C-1) - sc-7300 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CBP (C-1): sc-7300. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

CBP (451) - sc-1211 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CBP (451) : sc-1211. Western blot analysis of truncated rat recombinant CBP CREB binding domain fusion protein.

CBP (A-22) - sc-369 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CBP (A-22): sc-369. Western blot analysis of CBP expression in KNRK nuclear extract.

CBP (H-300) - sc-20686 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CBP (H-300): sc-20686. Western blot analysis of human recombinant CBP fusion protein.

Anti-KAT3A / CBP (acetyl K1535) antibody - ab61242 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using CBP (acetyl K1535) antibody (ab61242) at 1/50 dilution, in the presence (right panel) or absence (left panel) of acetylated peptide.

Anti-KAT3A / CBP antibody - ab129117 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-KAT3A / CBP antibody (ab129117) at 1 µg/mlLane 1 : MCF7 (Human breast adenocarcinoma cell line) Whole Cell LysateLane 2 : U2OS (Human osteosarcoma cell line) Whole Cell LysateLane 3 : Caco 2 (Human colonic carcinoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-KAT3A / CBP antibody - ab128057 from Abcam

Prices $376.00
Sizes 125 µl
Host Mouse
Clonality Monoclonal
ab128057, at 1/25 dilution, staining KAT3A / CBP in paraffin-embedded Human testis tissue by Immunohistochemistry.

Anti-KAT3A / CBP antibody - ab52238 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-KAT3A / CBP antibody (ab52238) at 1/500 dilutionLane 1 : Extracts from HeLa cells treated with insulin (0.01U/ml, for 15min). Lane 2 : Extracts from HeLa cells treated with insulin (0.01U/ml, for 15min) and with the immunising peptide.

Anti-KAT3A / CBP antibody - ab55419 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-KAT3A / CBP antibody (ab55419) at 1/500 dilutionLane 1 : COLO205 cell extract, without immunizing peptideLane 2 : COLO205 cell extract, with immunizing peptide

Anti-KAT3A / CBP antibody - ab52718 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Polyclonal

Anti-KAT3A / CBP antibody [CBP5I001] - ab50702 from Abcam

Prices $385.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone CBP5I001
IHC image of KAT3A staining in human pancreas formalin fixed paraffin embedded tissue section, performed on a Leica Bond system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab50702, 10µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-KAT3A / CBP antibody [NM11] (Biotin) - ab79270 from Abcam

Prices $372.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone NM11

Anti-KAT3A / CBP antibody, prediluted - ab53901 from Abcam

Prices $376.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
Human tonsil tissue stained with neat ab53901

Anti-KAT3A / CBP antibody - ChIP Grade - ab2832 from Abcam

Prices $391.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KAT3A / CBP antibody - ChIP Grade - ab10490 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate carcinoma tissue labelling KAT3A / CBP with ab10490 at 1/500 (2µg/ml). Detection: DAB.

Anti-KAT3A / CBP antibody - ChIP Grade - ab10489 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab10489 immunoprecipitation of CREB Binding Protein. Samples: Nuclear (NE) or cytoplasmic (S100) extract (10 mg) from HeLa cells. Antibody: ab10489 used at 20 µg/10 mg extract.  Detection: Coomassie Brilliant Blue R250 staining of SDS-PAGE gel followed by mass spectrometry to confirm the identity of the band that is CREB Binding Protein .

Anti-CREBBP / CBP Antibody - LS-C12615 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CREBBP / CBP Antibody (Acetyl-Lys1535) - LS-C12619 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
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