CREBBP

Gene Symbol	CREBBP
Entrez Gene	1387
Alt Symbol	CBP, KAT3A, RSTS
Species	Human
Gene Type	protein-coding
Description	CREB binding protein
Other Description	CREB-binding protein
Swissprots	Q16376 D3DUC9 Q4LE28 Q92793 O00147
Accessions	AAC08447 AAC17736 ACF57233 ACF57234 ACF57235 ACF57236 ACF57237 ACF57238 ACF57239 ACF57240 ACF57241 ACF57242 ACF57243 ACF57244 ACF57245 ACF57246 ACF57247 ACF57248 ACF57249 ACF57250 ACF57251 ACF57252 ACF57253 ACF57254 ACF57255 ACF57256 ACF57257 ACF57258 ACF57259 ACF57260 ACF57261 ACF57262 ACF57263 ACF57264 ACF57265 ACF57266 ACF57267 ACF57268 ACF57269 ACF57270 ACF57271 ACF57272 ACF57273 ACF57274 ACF57275 ACF57276 CAL00150 CBX47651 CBX47652 EAW85334 EAW85335 EAW85336 EAW85337 Q92793 AB210043 BAE06125 AK124320 AK304771 BAG65526 BC036486 AAH36486 U47741 AAC51770 U85962 AAC51331 U89354 AAC51339 U89355 AAC51340 XM_005255124 XP_005255181 XM_005255125 XP_005255182 XM_006720848 XP_006720911 XM_011522380 XP_011520682 XM_011522381 XP_011520683 XM_011522382 XP_011520684 NM_001079846 NP_001073315 NM_004380 NP_004371
Function	Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2- ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. {ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:9707565}.
Subcellular Location	Cytoplasm. Nucleus. Note=Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus.
Top Pathways	Viral carcinogenesis, Glucagon signaling pathway, Epstein-Barr virus infection, MicroRNAs in cancer, cAMP signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human KAT3A / CBP protein fragment - ab167964 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human KAT3A / CBP protein fragment - ab198130 from Abcam Category Protein Prices $837.00 Sizes 100 µg Source E. coli Species Human

Human KAT3A / CBP peptide - ab4916 from Abcam Category Peptide Species Human

Human KAT3A / CBP protein fragment - ab135297 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human KAT3A / CBP protein fragment - ab198144 from Abcam Category Protein Source E. coli Species Human

Human KAT3A / CBP protein fragment - ab56272 from Abcam Category Protein Source E. coli Species Human

CREBBP / CREB Binding Protein Antibody Blocking Peptide - LS-E16045 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CBP/KAT3A Protein - H00001387-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CBP blocking peptide - GTX89050-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

CREBBP Blocking Peptide - 33R-9216 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human CREB Binding Protein Protein - abx066151 from Abbexa Category Protein Source E.coli Species Human

CREB-binding protein - H00001387-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CREB-binding protein - H00001387-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CREB-binding protein control peptide - SP5315CP from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

CREB Binding Protein (CREBBP), Human - 20-8878 from ARP American Research Products Category Protein Prices $469.00 Sizes 50 µg Source E.coli Species Human

Recombinant CREBBP (1081-1197) protein - 31373 from ActiveMotif Category Protein Prices $395.00, $2,600.00 Sizes 100 µg, 1 mg Source E. coli Species Human

Recombinant Human CREB Binding Protein, GST-tagged - CREBBP-1581H from Creative Biomart Category Protein Species Human

Recombinant Human CREBBP - CREBBP-28400TH from Creative Biomart Category Protein Source E. coli

Recombinant Human CREBBP, GST-tagged - CREBBP-192H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus Species Human

Recombinant Human CREB Binding Protein, GST-tagged - CREBBP-1442H from Creative Biomart Category Protein Source E.coli.

Recombinant CREB Binding Protein (CREBBP) - RPE002Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant CREB Binding Protein (CREBBP) - RPE002Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant CREB Binding Protein (CREBBP) - RPE002Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

CBP (catalytic domain) human recombinant - 03-189 from EMD Millipore Prices $455.00 Sizes 100 µg Source Catalytic domain (residues 1319-1710) of human CBP histone acetyltransferase Species Human

CBP protein-GST fusion - 009-001-R59 from Rockland Immunochemicals Inc Category Protein Prices $499.00 Sizes 50 µg Species Human

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