| Gene Symbol | DARS |
|---|---|
| Entrez Gene | 1615 |
| Alt Symbol | HBSL, aspRS |
| Species | Human |
| Gene Type | protein-coding |
| Description | aspartyl-tRNA synthetase |
| Other Description | aspartate tRNA ligase 1, cytoplasmic|aspartate--tRNA ligase, cytoplasmic|aspartyl-tRNA synthetase, cytoplasmic|cell proliferation-inducing gene 40 protein |
| Swissprots | Q32Q69 D3DP77 Q2TNI3 P14868 A8K3J2 Q53YC5 Q68CR9 Q53HV4 Q9BW52 |
| Accessions | AAY15029 AAY24055 EAX11617 EAX11618 EAX11619 EAX11620 P14868 AK129521 AK222476 BAD96196 AK290607 BAF83296 AY762100 AAX07827 BC000629 AAH00629 BC107749 AAI07750 BI753718 BT006710 AAP35356 BU615302 BX101357 CR749809 CAH18669 DA597505 DQ890741 ABM81667 DQ893912 ABM84838 J05032 AAA35567 NM_001293312 NP_001280241 NM_001349 NP_001340 |
| Function | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Expression in the developing and adult brain shows similar patterns. Highly expressed in the ventricular and subventricular zones, including hippocampal subfields, the midlateral temporaal cortex and the frontal polar cortex. The cerebellum, cereral cortex, hippocampus, and lateral ventricle show preferential neuronal expression. Expression in the peripheral neurons is evident in the colon. {ECO:0000269|PubMed:23643384}. |
| Top Pathways | Aminoacyl-tRNA biosynthesis |