Gene Symbol | DARS |
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Entrez Gene | 1615 |
Alt Symbol | HBSL, aspRS |
Species | Human |
Gene Type | protein-coding |
Description | aspartyl-tRNA synthetase |
Other Description | aspartate tRNA ligase 1, cytoplasmic|aspartate--tRNA ligase, cytoplasmic|aspartyl-tRNA synthetase, cytoplasmic|cell proliferation-inducing gene 40 protein |
Swissprots | Q32Q69 D3DP77 Q2TNI3 P14868 A8K3J2 Q53YC5 Q68CR9 Q53HV4 Q9BW52 |
Accessions | AAY15029 AAY24055 EAX11617 EAX11618 EAX11619 EAX11620 P14868 AK129521 AK222476 BAD96196 AK290607 BAF83296 AY762100 AAX07827 BC000629 AAH00629 BC107749 AAI07750 BI753718 BT006710 AAP35356 BU615302 BX101357 CR749809 CAH18669 DA597505 DQ890741 ABM81667 DQ893912 ABM84838 J05032 AAA35567 NM_001293312 NP_001280241 NM_001349 NP_001340 |
Function | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. |
Subcellular Location | Cytoplasm. |
Tissue Specificity | Expression in the developing and adult brain shows similar patterns. Highly expressed in the ventricular and subventricular zones, including hippocampal subfields, the midlateral temporaal cortex and the frontal polar cortex. The cerebellum, cereral cortex, hippocampus, and lateral ventricle show preferential neuronal expression. Expression in the peripheral neurons is evident in the colon. {ECO:0000269|PubMed:23643384}. |
Top Pathways | Aminoacyl-tRNA biosynthesis |
Human DARS full length protein - ab124568 from Abcam
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DARS Antibody Blocking Peptide - LS-E733 from LifeSpan Bioscience
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DARS Recombinant Protein - H00001615-P01 from Novus Biologicals
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DARS Partial Recombinant Protein - H00001615-Q01 from Novus Biologicals
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Recombinant Human DARS Protein - NBP1-99067 from Novus Biologicals
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DARS-Antibody-N-term-Blocking-peptide - BP11088a from Abgent, a WuXi AppTec company
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Human DARS protein - orb168192 from Biorbyt
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Human DARS protein (His Tag) - orb138677 from Biorbyt
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DARS protein (His tag) - 80R-2197 from Fitzgerald
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DARS1 (1-501, His-tag) - AR50279PU-N from Acris Antibodies
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DARS1 (1-501, His-tag) - AR50279PU-S from Acris Antibodies
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DARS1 - H00001615-P01-10 from Acris Antibodies
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DARS1 - H00001615-P01-25 from Acris Antibodies
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DARS1 - H00001615-Q01-10 from Acris Antibodies
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DARS1 - H00001615-Q01-25 from Acris Antibodies
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DARS, 1-501aa, Human, His tag, E.coli - 01-P1454 from ARP American Research Products
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DARS fusion protein - Ag6974 from Proteintech Group
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DARS fusion protein - ag7059 from Proteintech Group
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DARS Human - ENPS-598 from NeoScientific
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Recombinant Human Aspartyl-tRNA Synthetase Enzyme - BP002781-ENZ-591 from Syd Labs
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Recombinant Human DARS, GST-tagged - DARS-11831H from Creative Biomart
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Recombinant Human DARS, His tagged - DARS-564H from Creative Biomart
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Recombinant Human DARS, His-tagged - DARS-3672H from Creative Biomart
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Human DARS Protein (His Tag) - 14278-H07E-20 from Sino Biological
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Recombinant Human Aspartate--tRNA ligase, cytoplasmic(DARS) - CSB-YP006505HU CSB-EP006505HU CSB-BP006505HU CSB-MP006505HU from Cusabio
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