| Gene Symbol |
ARAP3
|
| Entrez Gene |
64411
|
| Alt Symbol |
CENTD3, DRAG1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
|
| Other Description |
ARF-GAP, RHO-GAP, ankyrin repeat and plekstrin homology domains-containing protein 3|Arf and Rho GAP adapter protein 3|PtdIns(3,4,5)P3-binding protein|arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3|centaurin, delta 3|centaurin-delta-3|cnt-d3|phosphoinositide binding protein
|
| Swissprots |
D3DQE3 Q8WWN8 B4DIT1
|
| Accessions |
EAW61904 EAW61905 EAW61906 EAW61907 Q8WWN8 AJ310567 CAC83946 AK001579 BAG50942 AK024718 BAB14973 AK091385 AK290052 BAF82741 AK295768 BAG58593 BC009968 AAH09968 BC025757 AAH25757 BC027880 AAH27880 BX489939 XM_005268497 XP_005268554 XM_005268498 XP_005268555 XM_005268499 XP_005268556 XM_005268500 XP_005268557 XM_006714792 XP_006714855 XM_011537677 XP_011535979 XR_944326 XR_944327 XR_944328 XR_944329 NM_022481 NP_071926
|
| Function |
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin. {ECO:0000269|PubMed:11804589, ECO:0000269|PubMed:15569923}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Cytoplasmic, and associated with F-actin-rich membrane ruffles and lamellipodia. {ECO:0000250}.
|
| Top Pathways |
Endocytosis, cAMP signaling pathway, Rap1 signaling pathway
|
![Western Blot: ARAP3 Overexpression Lysate (Adult Normal) [NBP2-06429] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ARAP3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6644_ARAP3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06429-img0001.jpg)