ARAP3

Gene Symbol	ARAP3
Entrez Gene	64411
Alt Symbol	CENTD3, DRAG1
Species	Human
Gene Type	protein-coding
Description	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Other Description	ARF-GAP, RHO-GAP, ankyrin repeat and plekstrin homology domains-containing protein 3|Arf and Rho GAP adapter protein 3|PtdIns(3,4,5)P3-binding protein|arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3|centaurin, delta 3|centaurin-delta-3|cnt-d3|phosphoinositide binding protein
Swissprots	D3DQE3 Q8WWN8 B4DIT1
Accessions	EAW61904 EAW61905 EAW61906 EAW61907 Q8WWN8 AJ310567 CAC83946 AK001579 BAG50942 AK024718 BAB14973 AK091385 AK290052 BAF82741 AK295768 BAG58593 BC009968 AAH09968 BC025757 AAH25757 BC027880 AAH27880 BX489939 XM_005268497 XP_005268554 XM_005268498 XP_005268555 XM_005268499 XP_005268556 XM_005268500 XP_005268557 XM_006714792 XP_006714855 XM_011537677 XP_011535979 XR_944326 XR_944327 XR_944328 XR_944329 NM_022481 NP_071926
Function	Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin. {ECO:0000269|PubMed:11804589, ECO:0000269|PubMed:15569923}.
Subcellular Location	Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Cytoplasmic, and associated with F-actin-rich membrane ruffles and lamellipodia. {ECO:0000250}.
Top Pathways	Endocytosis, cAMP signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ARAP3 peptide - ab23118 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

ARAP3 Antibody Blocking Peptide - LS-E25603 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ARAP3 Recombinant Protein - H00064411-P01 from Novus Biologicals Category Protein Species Human

CENTD3/ARAP3 blocking peptide - GTX25911-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

ARAP3 Peptide - AC21-0433-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

ARAP3 / CENTD3 - H00064411-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Source in vitro transl. Species Human

ARAP3 / CENTD3 - H00064411-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Source in vitro transl. Species Human

ARAP3 Peptide - 45-276P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

ARAP3 fusion protein - Ag17436 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

CENTD3 fusion protein - ag1479 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human ARAP3, His-tagged - ARAP3-9792H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3(ARAP3) ,partial - CSB-YP819904HU CSB-EP819904HU CSB-BP819904HU CSB-MP819904HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ARAP3 / CENTD3 - TP321115 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3(ARAP3) ,partial, Recombinant Protein - MBS1408962 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

ARAP3, Peptide - MBS426755 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Dog, Pig, Bovine

ARAP3 Recombinant Protein Antigen - NBP1-84541PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ARAP3 Peptide, Human - M34GP00825H from Creative Peptides Category Peptide Source Synthetic. Species Human

CENTD3 fusion protein - Ag24116 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

CENTD3 Immunizing peptide - orb17818 from Biorbyt Category Peptide

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