ARAP3

Gene Symbol ARAP3
Entrez Gene 64411
Alt Symbol CENTD3, DRAG1
Species Human
Gene Type protein-coding
Description ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Other Description ARF-GAP, RHO-GAP, ankyrin repeat and plekstrin homology domains-containing protein 3|Arf and Rho GAP adapter protein 3|PtdIns(3,4,5)P3-binding protein|arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3|centaurin, delta 3|centaurin-delta-3|cnt-d3|phosphoinositide binding protein
Swissprots D3DQE3 Q8WWN8 B4DIT1
Accessions EAW61904 EAW61905 EAW61906 EAW61907 Q8WWN8 AJ310567 CAC83946 AK001579 BAG50942 AK024718 BAB14973 AK091385 AK290052 BAF82741 AK295768 BAG58593 BC009968 AAH09968 BC025757 AAH25757 BC027880 AAH27880 BX489939 XM_005268497 XP_005268554 XM_005268498 XP_005268555 XM_005268499 XP_005268556 XM_005268500 XP_005268557 XM_006714792 XP_006714855 XM_011537677 XP_011535979 XR_944326 XR_944327 XR_944328 XR_944329 NM_022481 NP_071926
Function Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin. {ECO:0000269|PubMed:11804589, ECO:0000269|PubMed:15569923}.
Subcellular Location Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Cytoplasmic, and associated with F-actin-rich membrane ruffles and lamellipodia. {ECO:0000250}.
Top Pathways Endocytosis, cAMP signaling pathway, Rap1 signaling pathway

ARAP3 CRISPR/Cas9 KO Plasmid (h) - sc-405365 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARAP3 HDR Plasmid (h) - sc-405365-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARAP3 Double Nickase Plasmid (h) - sc-405365-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARAP3 Double Nickase Plasmid (h2) - sc-405365-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARAP3 CRISPR Activation Plasmid (h) - sc-405365-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARAP3 CRISPR Activation Plasmid (h2) - sc-405365-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARAP3 Lentiviral Activation Particles (h) - sc-405365-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARAP3 Lentiviral Activation Particles (h2) - sc-405365-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARAP3 siRNA (h) - sc-61988 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ARAP3 shRNA Plasmid (h) - sc-61988-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ARAP3 shRNA (h) Lentiviral Particles - sc-61988-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU090481 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3383 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3383 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ARAP3 siRNA (Human) - CRJ2011 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ARAP3 - MBS8236611 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ARAP3 (NM_022481.5) - SHH239014 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human CENTD3(NM_022481.5) - SHG067699 from Creative biogene

Category siRNA
Species Reactivities Human

ARAP3 shRNA Plasmid (Human) - CHJ2011 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ARAP3 miRNA 3'UTR clone - MiUTR1H-02047 from Creative biogene

Species Reactivities Human
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