Gene Symbol | ARAP3 |
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Entrez Gene | 64411 |
Alt Symbol | CENTD3, DRAG1 |
Species | Human |
Gene Type | protein-coding |
Description | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 |
Other Description | ARF-GAP, RHO-GAP, ankyrin repeat and plekstrin homology domains-containing protein 3|Arf and Rho GAP adapter protein 3|PtdIns(3,4,5)P3-binding protein|arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3|centaurin, delta 3|centaurin-delta-3|cnt-d3|phosphoinositide binding protein |
Swissprots | D3DQE3 Q8WWN8 B4DIT1 |
Accessions | EAW61904 EAW61905 EAW61906 EAW61907 Q8WWN8 AJ310567 CAC83946 AK001579 BAG50942 AK024718 BAB14973 AK091385 AK290052 BAF82741 AK295768 BAG58593 BC009968 AAH09968 BC025757 AAH25757 BC027880 AAH27880 BX489939 XM_005268497 XP_005268554 XM_005268498 XP_005268555 XM_005268499 XP_005268556 XM_005268500 XP_005268557 XM_006714792 XP_006714855 XM_011537677 XP_011535979 XR_944326 XR_944327 XR_944328 XR_944329 NM_022481 NP_071926 |
Function | Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin. {ECO:0000269|PubMed:11804589, ECO:0000269|PubMed:15569923}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Cytoplasmic, and associated with F-actin-rich membrane ruffles and lamellipodia. {ECO:0000250}. |
Top Pathways | Endocytosis, cAMP signaling pathway, Rap1 signaling pathway |
ARAP3 CRISPR/Cas9 KO Plasmid (h) - sc-405365 from Santa Cruz Biotechnology
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ARAP3 HDR Plasmid (h) - sc-405365-HDR from Santa Cruz Biotechnology
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ARAP3 Double Nickase Plasmid (h) - sc-405365-NIC from Santa Cruz Biotechnology
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ARAP3 Double Nickase Plasmid (h2) - sc-405365-NIC-2 from Santa Cruz Biotechnology
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ARAP3 CRISPR Activation Plasmid (h) - sc-405365-ACT from Santa Cruz Biotechnology
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ARAP3 CRISPR Activation Plasmid (h2) - sc-405365-ACT-2 from Santa Cruz Biotechnology
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ARAP3 Lentiviral Activation Particles (h) - sc-405365-LAC from Santa Cruz Biotechnology
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ARAP3 Lentiviral Activation Particles (h2) - sc-405365-LAC-2 from Santa Cruz Biotechnology
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ARAP3 siRNA (h) - sc-61988 from Santa Cruz Biotechnology
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ARAP3 shRNA Plasmid (h) - sc-61988-SH from Santa Cruz Biotechnology
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ARAP3 shRNA (h) Lentiviral Particles - sc-61988-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU090481 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3383 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3383 from Sigma-Aldrich
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ARAP3 siRNA (Human) - CRJ2011 from Cohesion Biosciences
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ARAP3 - MBS8236611 from MyBioSource
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shRNA set against Human ARAP3 (NM_022481.5) - SHH239014 from Creative biogene
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shRNA set against Human CENTD3(NM_022481.5) - SHG067699 from Creative biogene
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ARAP3 shRNA Plasmid (Human) - CHJ2011 from Cohesion Biosciences
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ARAP3 miRNA 3'UTR clone - MiUTR1H-02047 from Creative biogene
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