RARA

Gene Symbol	RARA
Entrez Gene	5914
Alt Symbol	NR1B1, RAR
Species	Human
Gene Type	protein-coding
Description	retinoic acid receptor, alpha
Other Description	RAR-alpha|nuclear receptor subfamily 1 group B member 1|nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form|retinoic acid nuclear receptor alpha variant 1|retinoic acid nuclear receptor alpha variant 2|retinoic acid receptor alpha|retinoic acid receptor, alpha polypeptide
Swissprots	P78456 B8Y636 Q9NQS0 P10276
Accessions	AAD05222 AAD13888 AAF87249 CAA39533 CAM91168 EAW60652 EAW60653 EAW60654 EAW60655 EAW60656 EAW60657 EAW60658 P10276 AK098172 BAG53585 AK130192 AK292205 BAF84894 AK303868 BAG64806 AK312564 BAG35459 AL522713 AL834159 CAH56277 BC008727 AAH08727 BC071733 AAH71733 BG394590 BM838347 BM992549 BY799725 CB105313 CR457438 CAG33719 DA061829 DA541711 DQ893531 ABM84457 DQ893744 ABM84670 FJ487576 ACK86665 HQ692826 ADZ17337 HQ692827 ADZ17338 S50916 AAB19602 X06538 CAA29787 X06614 CAA29829 X58685 CAA41532 XM_005257552 XP_005257609 XM_005257553 XP_005257610 XM_005257554 XP_005257611 XM_011525095 XP_011523397 XM_011525096 XP_011523398 NM_000964 NP_000955 NM_001024809 NP_001019980 NM_001145301 NP_001138773 NM_001145302 NP_001138774 NM_001033603
Function	Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meio
Subcellular Location	Nucleus. Cytoplasm. Note=Nuclear localization depends on ligand binding, phosphorylation and sumoylation. Transloaction to the nucleus in the absence of ligand is dependent on activation of PKC and the downstream MAPK phosphorylation.
Top Pathways	Acute myeloid leukemia, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RARA / RAR Alpha ELISA Kit (Sandwich ELISA) - LS-F4676 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.056 ng/ml Range 0.156-10 ng/ml

Mouse/Human Phospho-RARA / RAR Alpha (Ser77) ELISA Kit (DNA-Binding Phosphorylation ELISA) - LS-F906 from LifeSpan Bioscience Category ELISA Kit Prices $750.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human/Rat RARA / RAR Alpha ELISA Kit (DNA-Binding ELISA) - LS-F809 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Range 0.156-10 ng/ml

Rat RARA / RAR Alpha ELISA Kit (Sandwich ELISA) - LS-F7870 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.114 ng/ml Range 0.156-10 ng/ml

Retinoic Acid Receptor Alpha, RARa, Human, ELISA Kit - E-EL-H2411 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Retinoic Acid Receptor Alpha (RARa), Human, ELISA Kit - SEA976Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.058ng/mL Range 0.156-10ng/mL

Retinoic acid receptor alpha (RARA), Human, ELISA Kit - E01R0394 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Retinoic acid receptor alpha, RARA, Human, ELISA Kit - E2297h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

Retinoic Acid Receptor Alpha, RARa, Rabbit, ELISA Kit - E-EL-RB0369 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Retinoic Acid Receptor Alpha, RARa, Chicken, ELISA Kit - E-EL-Ch0694 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Retinoic Acid Receptor Alpha, RARa, Porcine, ELISA Kit - E-EL-P1417 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Retinoic Acid Receptor Alpha, RARa, Sheep, ELISA Kit - E-EL-S0268 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Retinoic Acid Receptor Alpha, RARa, Monkey, ELISA Kit - E-EL-MK2039 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Retinoic Acid Receptor Alpha, ELISA Kit - MBS052476 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Retinoic Acid Receptor Alpha (RARa), ELISA Kit - MBS2022681 from MyBioSource Category ELISA Kit Prices $345.00, $515.00, $695.00, $2,840.00, $5,180.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human RARa is typically less than 0.058ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration. Range 0.156-10ng/mL

Retinoic acid receptor alpha (RARA), ELISA Kit - MBS7231784 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Retinoic acid receptor alpha (RARA), ELISA Kit - MBS7206970 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Retinoic Acid Receptor Alpha (RARa), ELISA Kit - MBS9309243 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Retinoic Acid Receptor Alpha (RARa), ELISA Kit - MBS9307463 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Retinoic acid receptor alpha (RARA), ELISA Kit - MBS7222093 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Retinoic acid receptor alpha (RARA), ELISA Kit - MBS7235184 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Retinoic acid receptor alpha (RARA), ELISA Kit - MBS7221645 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Retinoic acid receptor Alpha (RARA), ELISA Kit - MBS7239335 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Retinoic acid receptor alpha (RARA), ELISA Kit - MBS7244466 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Retinoic acid receptor alpha (RARA), ELISA Kit - MBS7208129 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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