RARA

Gene Symbol	RARA
Entrez Gene	5914
Alt Symbol	NR1B1, RAR
Species	Human
Gene Type	protein-coding
Description	retinoic acid receptor, alpha
Other Description	RAR-alpha|nuclear receptor subfamily 1 group B member 1|nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form|retinoic acid nuclear receptor alpha variant 1|retinoic acid nuclear receptor alpha variant 2|retinoic acid receptor alpha|retinoic acid receptor, alpha polypeptide
Swissprots	P78456 B8Y636 Q9NQS0 P10276
Accessions	AAD05222 AAD13888 AAF87249 CAA39533 CAM91168 EAW60652 EAW60653 EAW60654 EAW60655 EAW60656 EAW60657 EAW60658 P10276 AK098172 BAG53585 AK130192 AK292205 BAF84894 AK303868 BAG64806 AK312564 BAG35459 AL522713 AL834159 CAH56277 BC008727 AAH08727 BC071733 AAH71733 BG394590 BM838347 BM992549 BY799725 CB105313 CR457438 CAG33719 DA061829 DA541711 DQ893531 ABM84457 DQ893744 ABM84670 FJ487576 ACK86665 HQ692826 ADZ17337 HQ692827 ADZ17338 S50916 AAB19602 X06538 CAA29787 X06614 CAA29829 X58685 CAA41532 XM_005257552 XP_005257609 XM_005257553 XP_005257610 XM_005257554 XP_005257611 XM_011525095 XP_011523397 XM_011525096 XP_011523398 NM_000964 NP_000955 NM_001024809 NP_001019980 NM_001145301 NP_001138773 NM_001145302 NP_001138774 NM_001033603
Function	Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meio
Subcellular Location	Nucleus. Cytoplasm. Note=Nuclear localization depends on ligand binding, phosphorylation and sumoylation. Transloaction to the nucleus in the absence of ligand is dependent on activation of PKC and the downstream MAPK phosphorylation.
Top Pathways	Acute myeloid leukemia, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-RARA-cDNA-Clone - DC08897 from Abgent, a WuXi AppTec company Prices $623.70 Sizes 10 µg Species Human Accession NM_000964

RARA - MBS1278888 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC071733

RARA - MBS1276337 from MyBioSource Species Human Accession BC008727

Human RARA transcript variant 1 Gene ORF cDNA clone in cloning vector - HG12119-M from Sino Biological Species Human

Human RARA transcript variant 1 Gene ORF cDNA clone expression plasmid, C-His tag - HG12119-CH from Sino Biological Species Human

Human RARA transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG12119-NF from Sino Biological Species Human

Human RARA transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG12119-NM from Sino Biological Species Human

Human RARA transcript variant 1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG12119-ACG from Sino Biological Species Human

Human RARA transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG12119-CF from Sino Biological Species Human

Human RARA transcript variant 1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG12119-ANG from Sino Biological Species Human

Human RARA transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG12119-CM from Sino Biological Species Human

Human RARA transcript variant 1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG12119-CY from Sino Biological Species Human

Human RARA transcript variant 1 Gene ORF cDNA clone expression plasmid - HG12119-UT from Sino Biological Species Human

Human RARA transcript variant 1 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG12119-M-N from Sino Biological Species Human Accession NM_000964.2

Human RARA transcript variant 1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG12119-NY from Sino Biological Species Human

Human RARA transcript variant 1 Gene ORF cDNA clone expression plasmid, N-His tag - HG12119-NH from Sino Biological Species Human

Human RARA ORF Clone (BC008727) - CDCS406021 from Creative biogene Species Human Accession P10276

Human RARA ORF Clone (BC071733) - CDCS406022 from Creative biogene Species Human Accession P10276

Human RARA ORF clone (NM_000964.2) - CDCB160251 from Creative biogene Species Human

Human RARA gene - orb92509 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

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